JAK2 V617F is one of three defining drivers in primary myelofibrosis (~50-60%; CALR ~25%,...
Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.
| ID | BMA-JAK2-V617F-PMF |
|---|---|
| Type | Actionability |
| Status | reviewed 2026-04-27 | pending_clinical_signoff | actionability review required |
| Diseases | DIS-PMF |
| Sources | SRC-CIVIC SRC-COMFORT-I-VERSTOVSEK-2012 SRC-DIPSS-PLUS-GANGAT-2011 SRC-ESMO-MPN-2015 SRC-JAKARTA2-HARRISON-2017 SRC-MOMENTUM-VERSTOVSEK-2023 SRC-NCCN-MPN-2025 |
Actionability Facts
| Biomarker | BIO-JAK2 |
|---|---|
| Variant | V617F (exon 14 — present in ~50-60% of primary myelofibrosis) |
| Disease | DIS-PMF |
| ESCAT tier | IA |
| Recommended combinations | ruxolitinib monotherapy (intermediate-2 / high-risk per SRC-COMFORT-I-VERSTOVSEK-2012, SRC-NCCN-MPN-2025), fedratinib monotherapy (post-ruxolitinib failure per SRC-JAKARTA2-HARRISON-2017), momelotinib monotherapy (MF + anemia per SRC-MOMENTUM-VERSTOVSEK-2023), allogeneic HCT (transplant-eligible higher-risk per SRC-NCCN-MPN-2025, SRC-DIPSS-PLUS-GANGAT-2011) |
| Evidence summary | JAK2 V617F is one of three defining drivers in primary myelofibrosis (~50-60%; CALR ~25%, MPL ~5-10%, triple-negative ~10%) and a WHO 2022 / ICC 2022 major diagnostic criterion (per SRC-NCCN-MPN-2025, SRC-ESMO-MPN-2015). Treatment by symptom burden / risk score (DIPSS- Plus, MIPSS70, MIPSS70+v2): symptomatic intermediate/high-risk → ruxolitinib (COMFORT-I Verstovsek 2012 — 41.9% spleen response vs 0.7% placebo, OS benefit on extended follow-up); fedratinib for ruxolitinib-failure (JAKARTA2 Harrison 2017 — 31% spleen response in RUX-failure); momelotinib for anemic patients (MOMENTUM Verstovsek 2023 — superior anemia + symptom benefit vs danazol). Allogeneic HCT is the only curative therapy and is recommended for transplant- eligible higher-risk patients per SRC-NCCN-MPN-2025. |
Notes
ESCAT IA / OncoKB Level 1 — JAK-inhibitor therapy is genotype- agnostic (works for V617F, CALR, MPL, and triple-negative MF) because it targets downstream activated JAK-STAT signaling rather than the upstream mutation. Risk stratification (DIPSS-Plus, MIPSS70+v2) considers V617F allele burden indirectly via cytogenetics / molecular high-risk features. Source-gap: SRC-NCCN-MPN-2025 STUB.
Used By
No reverse references found in the YAML corpus.