Onco Wiki / Biomarqueur

État du VHB (HBsAg + sérologie anti-HBc)

Vue déterministe de l'entité source de la LJAM. L'autorité clinique demeure avec les ID de la source cités et l'état d'approbation de l ́examinateur.

IDBIO-HBV-STATUS
TypeBiomarqueur
Alias
Sérologie du VHBHBsAg/anti-HBcDépistage de l'hépatite BÉtat du virus de l'hépatite BСтатус HBV (HBsAg + анти-HBc серологія)
Étatreviewed 2026-04-26 | pending_clinical_signoff
MaladiesDIS-CHL DIS-DLBCL-NOS DIS-HCC DIS-MM DIS-PTLD
SourcesSRC-AASLD-HCC-2023 SRC-NCCN-BCELL-2025

Données biomarqueurs

Type de biomarqueurviral_serology
Mesure
MéthodeThree-marker screening before B-cell-depleting or anti-CD38 therapy: HBsAg (current infection), anti-HBc total (past or occult infection), anti-HBs (immunity). HBV-DNA quantitative PCR follows when HBsAg+ or anti-HBc+ to distinguish active vs resolved infection.
Unitéscategorical: HBsAg+ | anti-HBc+/HBsAg- (occult) | naive | vaccinated
Biomarqueurs connexesBIO-HCV-STATUS BIO-HIV-STATUS

Notes

Mandatory pre-treatment screening for any regimen containing rituximab, obinutuzumab, daratumumab, isatuximab, blinatumomab, or other B-cell-depleting / plasma-cell-depleting agents (HBV reactivation risk well-documented; ASH/ASCO/AASLD all align). Rules engine consumes as boolean flag: HBsAg+ OR anti-HBc+ → RF-HBV-COINFECTION fires → forces entecavir prophylaxis (or tenofovir if entecavir resistance) before any cycle of CD20/CD38-targeted therapy. Wired into CHL, DLBCL, MM, SMZL, Burkitt 1L algorithms. Subtypes informally: - HBsAg+ (active or chronic): prophylaxis mandatory; consult hepatology - HBsAg- / anti-HBc+ (resolved or occult): prophylaxis still recommended for high-risk regimens (rituximab-containing); HBV-DNA monitoring acceptable for low-risk regimens - HBsAg- / anti-HBc- / anti-HBs+ (vaccinated): no prophylaxis - All-negative (naive): no prophylaxis; consider vaccination if multi-line therapy anticipated reviewer_signoffs: 0 # STUB — pending two Clinical Co-Lead approvals

Utilisé par

Pertinence thérapeutique

Algorithmes

Biomarqueur

Chapitres du manuel

Questions du manuel

Indication

Questionnaires