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HCV-RNA quantitativ — Viruslastüberwachung während einer direkt wirkenden antiviralen (DAA) Therapie

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IDBIO-HCV-RNA-QUANTITATIVE-MONITORING
ArtBiomarker
Aliase
HCV PCR quantitativHCV-RNA-Quantitative ÜberwachungÜberwachung der HCV-ViruslastHCV РНК кількісна — моніторинг вірусного навантаження під час DAA-терапіїBewertung der SVR12
Statusreviewed 2026-05-18 | pending_clinical_signoff
ErkrankungenDIS-HCV-MZL
QuellenSRC-AASLD-IDSA-HCV-2023 SRC-EASL-HCV-2023

Biomarker-Fakten

Biomarker-Typviral_load
Messung
VerfahrenReal-time quantitative PCR (HCV RNA, IU/mL); high-sensitivity assay (LOD ≤15 IU/mL) required for SVR12
EinheitenIU/mL
Typischer Bereich
  • 0
  • 100000000
Verwandte BiomarkerBIO-HCV-RNA BIO-HCV-STATUS

Anmerkungen

Quantitative HCV RNA used to TRACK response over time during 8-12 week course of direct-acting antiviral (DAA) regimens (glecaprevir/ pibrentasvir, sofosbuvir/velpatasvir, sofosbuvir/velpatasvir/voxilaprevir, ledipasvir/sofosbuvir). Distinct from BIO-HCV-RNA which captures the single-timepoint quantitative result; this entry captures the serial-monitoring concept for HCC prevention pathway. AASLD-IDSA / EASL minimum testing protocol: baseline HCV RNA + genotype + cirrhosis staging; on-treatment HCV RNA at week 4 (optional, evaluates adherence/response — undetectable at week 4 = rapid virologic response, RVR; not a stopping rule for modern DAAs); end-of-treatment HCV RNA at completion (week 8 or 12); SVR12 — undetectable HCV RNA 12 weeks after treatment completion = virologic cure (>95% achievable with current DAAs, durable in >99%). SVR12 = primary efficacy endpoint for HCV cure; SVR24 essentially equivalent. Post-SVR HCC surveillance remains REQUIRED in cirrhotic patients (cumulative HCC risk reduced but not eliminated by cure; AASLD recommends ongoing q6-month US ± AFP for cirrhotics regardless of SVR status). Quantitative monitoring also informs reinfection detection (any HCV R...

Verwendet von

Therapeutische Relevanz