Synthetic educational example. Do not self-treat: a qualified treating physician must verify the sources, patient data, contraindications, and final plan.
Patient
VERIFIED-GASTRIC-L1-GASTRIC_OLIGOMET_SYSTEMIC_PLUS · Algorithm: ALGO-GASTRIC-METASTATIC-1L
Clinical significance of mutations (ESCAT)
Tumor-board context — the engine does not use these tiers to rank tracks
| Biomarker | Variant | ESCAT | Evidence | Clinical significance | Drugs | Sources |
|---|
| No clinically actionable variants matched in this profile. |
Primary current-line option
- Indication
- IND-GASTRIC-OLIGOMET-SYSTEMIC-PLUS-LOCAL
- Regimen
- FLOT
- Drugs + NSZU
- Docetaxel (DRUG-DOCETAXEL) 50 mg/m² · IV over 1h, day 1 of 14-day cycle · IV ✓ NSZU covered
- Oxaliplatin (DRUG-OXALIPLATIN) 85 mg/m² · IV over 2h, day 1 · IV ✓ NSZU covered
- Leucovorin (DRUG-LEUCOVORIN) 200 mg/m² · IV over 30 min, day 1 (concurrent with oxaliplatin) · IV ⚠ NSZU — not for this indication
- 5-Fluorouracil (DRUG-5-FLUOROURACIL) 2600 mg/m² CIV over 24h · Day 1, continuous infusion via ambulatory pump · IV ✓ NSZU covered
- Reason
- Primary current-line option selected by ALGO-GASTRIC-METASTATIC-1L at step 0; branch-driving red flag: RF-OLIGOMET-DEFINITION.
Other current-line alternatives (4 tracks)
Same treatment line; review when biomarker, access, contraindication, or patient-context assumptions change.
- Indication
- IND-GASTRIC-METASTATIC-1L-HER2-TOGA
- Regimen
- Trastuzumab + capecitabine + cisplatin (TOGA / KEYNOTE-811)
- Drugs + NSZU
- Trastuzumab (DRUG-TRASTUZUMAB) 8 mg/kg IV loading then 6 mg/kg q3w · IV day 1 every 21d · IV ✓ NSZU covered
- Capecitabine (DRUG-CAPECITABINE) 1000 mg/m² PO BID days 1-14 · PO days 1-14 · PO ✓ NSZU covered
- Cisplatin (DRUG-CISPLATIN) 80 mg/m² · IV day 1 q3w · IV ⚠ NSZU — not for this indication
- Reason
- Current-line alternative presented for HCP consideration
- Indication
- IND-GASTRIC-METASTATIC-1L-CLDN18-2-ZOLBETUXIMAB
- Regimen
- Zolbetuximab + mFOLFOX6 (SPOTLIGHT) — 1L CLDN18.2-positive HER2-negative gastric/GEJ
- Drugs + NSZU
- Zolbetuximab (DRUG-ZOLBETUXIMAB) Loading 800 mg/m² IV cycle 1 day 1; maintenance 600 mg/m² IV q2w · IV q2w (with mFOLFOX6 backbone) · IV ✗ Not registered in UA
- Oxaliplatin (DRUG-OXALIPLATIN) 85 mg/m² IV day 1 · IV day 1 q2w · IV ✓ NSZU covered
- Leucovorin (DRUG-LEUCOVORIN) 400 mg/m² IV day 1 · IV day 1 q2w · IV ⚠ NSZU — not for this indication
- 5-Fluorouracil (DRUG-5-FLUOROURACIL) 400 mg/m² IV bolus day 1, then 2400 mg/m² IV continuous infusion over 46 h · IV q2w · IV ✓ NSZU covered
- Supportive care
- SUP-ANTIEMETIC-PREMED
- Reason
- Current-line alternative presented for HCP consideration
- Indication
- IND-GASTRIC-METASTATIC-1L-FGFR2B-BEMARITUZUMAB
- Regimen
- Bemarituzumab + mFOLFOX6 (FORTITUDE-101) — 1L FGFR2b-overexpressing HER2-non-positive gastric/GEJ
- Drugs + NSZU
- Bemarituzumab (DRUG-BEMARITUZUMAB) 15 mg/kg IV q2w; cycle 1 day 8 additional 7.5 mg/kg loading dose (FORTITUDE-101 protocol) · IV q2w (with mFOLFOX6 backbone) + cycle 1 day 8 booster dose · IV ✗ Not registered in UA
- Oxaliplatin (DRUG-OXALIPLATIN) 85 mg/m² IV day 1 · IV day 1 q2w · IV ✓ NSZU covered
- Leucovorin (DRUG-LEUCOVORIN) 400 mg/m² IV day 1 · IV day 1 q2w · IV ⚠ NSZU — not for this indication
- 5-Fluorouracil (DRUG-5-FLUOROURACIL) 400 mg/m² IV bolus day 1, then 2400 mg/m² IV continuous infusion over 46 h · IV q2w · IV ✓ NSZU covered
- Reason
- Current-line alternative presented for HCP consideration
- Indication
- IND-GASTRIC-METASTATIC-1L-PDL1-CHEMO-ICI
- Regimen
- FOLFOX + Nivolumab
- Drugs + NSZU
- Oxaliplatin (DRUG-OXALIPLATIN) 85 mg/m² · IV day 1 every 14d · IV ✓ NSZU covered
- Leucovorin (DRUG-LEUCOVORIN) 400 mg/m² · IV day 1 · IV ⚠ NSZU — not for this indication
- 5-Fluorouracil (DRUG-5-FLUOROURACIL) 400 mg/m² IV bolus + 2400 mg/m² CIV over 46h · Day 1 bolus, day 1-2 CIV · IV ✓ NSZU covered
- Nivolumab (DRUG-NIVOLUMAB) 360 mg IV q3w (CheckMate-649 primary protocol; FDA-approved flat-dose alternatives 240 mg IV q2w or 480 mg IV q4w) · Primary: 360 mg q3w aligned with XELOX 21-d cycle. Alternatives: 240 mg q2w aligned with FOLFOX 14-d cycle (day 1) or 480 mg q4w (every other FOLFOX cycle) · IV ⚠ NSZU — not for this indication
- Hard contraindications
- CI-PEMBROLIZUMAB-AUTOIMMUNE
- Reason
- Current-line alternative presented for HCP consideration
Why this branch was chosen
Triggers from the patient profile that fired and drove the chosen branch.
Step 0 → branch IND-GASTRIC-OLIGOMET-SYSTEMIC-PLUS-LOCAL
- RF-OLIGOMET-DEFINITION ★ winner: Oligometastatic esophagogastric adenocarcinoma per OMEC-1 (OligoMetastatic Esophagogastric Cancer) European Delphi consensus (Kroese et al., Eur J Cancer 2023, PMID 36947929). Defined as ≤3 distant metastatic lesions amenable to local therapy in a patient with controllable primary disease and ECOG 0-1 fitness. Excluded scenarios: peritoneal carcinomatosis, leptomeningeal disease, >3 brain metastases. RENAISSANCE / AIO-FLOT5 trial (NCT02578368) eligibility narrower: ≤1 incurable organ-system involvement, no ascites, ≤1 retroperitoneal LN station — uses FLOT chemo ± surgical resection (gastrectomy/oesophagectomy + metastasectomy). Triggers MDT consideration of metastasis-directed local therapy (metastasectomy or SBRT) added to systemic chemo, and registration on RENAISSANCE-pattern trials where available.
SRC-OMEC-1-KROESE-2023SRC-RENAISSANCE-AIO-FLOT5SRC-NCCN-GASTRIC-2025SRC-NCCN-ESOPHAGEAL-2025SRC-ESMO-GASTRIC-2024SRC-ESMO-ESOPHAGEAL-2024
Pre-treatment investigations
Investigations before treatment start · critical / standard / desired · merged across tracks
| ID | Name | Priority | Category | Where to order | Needed for |
|---|
| TEST-CBC | Complete Blood Count with Differential | Critical | lab | — | aggressive |
| TEST-CMP | Comprehensive Metabolic Panel | Critical | lab | — | aggressive |
| TEST-CT-CHEST-ABDOMEN-PELVIS | CT chest + abdomen + pelvis with IV contrast | Critical | imaging | — | all tracks |
| TEST-LFT | Liver Function Tests (ALT, AST, bilirubin, ALP, GGT, albumin) | Critical | lab | — | aggressive |
| TEST-MSI-PCR-OR-NGS | MSI status by PCR or NGS | Critical | histology | CSD Lab: M065
CSD Lab ✓ (code TBC) | all tracks |
| TEST-HER2-IHC-ISH-IF-RAS-WT | HER2 IHC + reflex ISH (gastric scoring criteria) | Standard | histology | CSD Lab ✓ (code TBC) | all tracks |
| TEST-NGS-COMPREHENSIVE | Comprehensive NGS tumor panel (DNA + RNA, ≥300 genes) | Desired | histology | CSD Lab: M065 | desired (aggressive) |
Red flags — PRO / CONTRA aggressive
PRO-AGGRESSIVE
Triggers that push toward the aggressive track
- CLDN18.2 expression positive (≥75% of tumor cells with 2+/3+ membranous staining on VENTANA CLDN18 (43-14A) RxDx) in HER2-negative metastatic / unresectable gastric or GEJ adenocarcinoma — eligibility for zolbetuximab + fluoropyrimidine/oxaliplatin 1L (SPOTLIGHT mFOLFOX6 mOS 18.2 vs 15.5 mo HR 0.75; GLOW CAPOX mOS 14.4 vs 12.2 mo HR 0.77). Treatment-defining for the ~38% of HER2-negative gastric cohort. Hierarchy: HER2+ trastuzumab supersedes; MSI-H pembrolizumab supersedes; otherwise CLDN18.2+ → zolbetuximab.
Companion diagnostic VENTANA CLDN18 (43-14A) RxDx required (FDA- approved alongside zolbetuximab Oct 2024). Cutoff: ≥75% of tumor cells with 2+/3+ membranous staining. Major toxicity: nausea/vomiting (~70% any grade — severe in cycle 1…
RF-GASTRIC-CLDN18-2-ACTIONABLESRC-NCCN-GASTRIC-2025SRC-ESMO-GASTRIC-2024 - Surgical/endoscopic emergency in gastric/GEJ adenocarcinoma: massive upper-GI bleed requiring transfusion, gastric outlet obstruction with intolerance of oral intake, or perforation. Mandates urgent endoscopic / surgical / interventional management BEFORE systemic therapy initiation.
~30% of gastric cancer presents with obstruction or bleeding. Endoscopic stenting OR palliative/diversion surgery + nutritional support BEFORE chemo. Bevacizumab/ramucirumab additionally contraindicated for ≥28 days post-surgery.
RF-GASTRIC-EMERGENCY-BLEED-OBSTRUCTIONSRC-NCCN-GASTRIC-2025SRC-ESMO-GASTRIC-2024 - Treatment-defining biomarkers in metastatic gastric/GEJ adenocarcinoma: HER2+ (IHC 3+ OR 2+/ISH+) → trastuzumab+chemo TOGA / T-DXd 2L+; CLDN18.2+ (≥75% of tumor cells with 2+ membranous staining) → zolbetuximab+chemo SPOTLIGHT/GLOW; MSI-H → pembrolizumab mono; EBV+ subtype (TCGA molecular class) — distinct biology, ICI-favorable.
Sequential biomarker test cascade: HER2 IHC → ISH if 2+; PD-L1 CPS; MSI-H reflex; CLDN18.2 IHC. EBV by EBER-ISH if MSI-WT non-classic signet-ring. Multiple actionable biomarkers can co-exist (HER2+ MSI-H ~3% — ICI + trastuzumab…
RF-GASTRIC-HIGH-RISK-BIOLOGYSRC-NCCN-GASTRIC-2025SRC-ESMO-GASTRIC-2024 - Oligometastatic esophagogastric adenocarcinoma per OMEC-1 (OligoMetastatic Esophagogastric Cancer) European Delphi consensus (Kroese et al., Eur J Cancer 2023, PMID 36947929). Defined as ≤3 distant metastatic lesions amenable to local therapy in a patient with controllable primary disease and ECOG 0-1 fitness. Excluded scenarios: peritoneal carcinomatosis, leptomeningeal disease, >3 brain metastases. RENAISSANCE / AIO-FLOT5 trial (NCT02578368) eligibility narrower: ≤1 incurable organ-system involvement, no ascites, ≤1 retroperitoneal LN station — uses FLOT chemo ± surgical resection (gastrectomy/oesophagectomy + metastasectomy). Triggers MDT consideration of metastasis-directed local therapy (metastasectomy or SBRT) added to systemic chemo, and registration on RENAISSANCE-pattern trials where available.
OMEC-1 consensus criteria (Kroese et al., Eur J Cancer 2023): 1. ≤3 distant metastatic lesions (primary numerical threshold). 2. Includes metachronous oligo-recurrence ≥6 months after curative- intent treatment. 3. Required diagnostic…
RF-OLIGOMET-DEFINITIONSRC-OMEC-1-KROESE-2023SRC-RENAISSANCE-AIO-FLOT5SRC-NCCN-GASTRIC-2025
CONTRA-AGGRESSIVE
Hard contraindications to escalation
What NOT to do
Explicit prohibitive rules, each grounded in a regimen / supportive care / contraindication entity
Aggressive plan (IND-GASTRIC-OLIGOMET-SYSTEMIC-PLUS-LOCAL)
- Do NOT offer surgical metastasectomy without 4 cycles induction systemic chemo first (RENAISSANCE design requires response demonstration)
- Do NOT include peritoneal carcinomatosis, leptomeningeal disease, or >3 brain mets — these are explicit OMEC-1 exclusions
- Do NOT proceed without MDT review (medical onc + surgical onc + radiation onc)
- Do NOT initiate during ongoing GI bleed / obstruction — emergency management first (RF-GASTRIC-EMERGENCY-BLEED-OBSTRUCTION)
- Do NOT use in HER2-positive disease — route via dedicated HER2 trastuzumab + chemo track
Aggressive plan (IND-GASTRIC-METASTATIC-1L-HER2-TOGA)
- Do NOT use without baseline LVEF — trastuzumab cardiotoxic (q3-mo echo monitoring)
- Do NOT combine with anthracycline (cumulative cardiotoxicity)
- Do NOT initiate during ongoing GI bleed / obstruction
Aggressive plan (IND-GASTRIC-METASTATIC-1L-CLDN18-2-ZOLBETUXIMAB)
- Do not start zolbetuximab without confirmed CLDN18.2 ≥75% 2+/3+ by VENTANA RxDx — outside this range benefit is not proven.
- Do not prescribe zolbetuximab in HER2+ patients — TOGA trastuzumab+chemo takes priority.
- Do not prescribe zolbetuximab in MSI-H patients 1L — pembrolizumab (KEYNOTE-859) takes preference.
- Do not start without triplet antiemetic prophylaxis (5-HT3 + NK1-RA + dex) for cycle 1 — nausea/vomiting severe without it.
- Do not combine with ipilimumab/ICI outside of trials — combination safety unknown.
- Do not confirm the plan without funding pathway — zolbetuximab not registered in UA.
Aggressive plan (IND-GASTRIC-METASTATIC-1L-FGFR2B-BEMARITUZUMAB)
- Do not start bemarituzumab without confirmed FGFR2b IHC 2+/3+ ≥10% by validated IIIb-isoform-selective antibody — outside this range benefit is not proven.
- Do not use pan-FGFR2 IHC instead of FGFR2b-selective — IIIb isoform is the target; pan-FGFR2 does not differentiate isoforms.
- Do not prescribe in HER2+ patients — TOGA trastuzumab+chemo takes priority.
- Do not prescribe in MSI-H patients — pembrolizumab (KEYNOTE-859) takes preference.
- Do not start without baseline ophthalmology exam + serial monitoring plan — corneal events ~70% any-grade, ~25% grade ≥3.
- Do not confirm the plan without funding pathway — bemarituzumab not registered; access via named-patient / clinical-trial only.
- Do not combine with other FGFR-selective inhibitors or CLDN18.2-targeted therapy outside trials.
Standard plan (IND-GASTRIC-METASTATIC-1L-PDL1-CHEMO-ICI)
- Do NOT use without HER2 testing — HER2+ patients get trastuzumab+chemo instead
- Do NOT continue through Grade 3+ irAE without permanent ICI discontinuation consideration
- Do NOT initiate during ongoing GI bleed / obstruction
Timeline
Treatment timeline — derived from regimen + monitoring schedule
Aggressive plan
Induction · FLOT
14-day cycles × 8 cycles total in perioperative use (4 pre-op + 4 post-op per FLOT4 / Al-Batran 2019); regimen not used as ongoing systemic therapy beyond periop
Aggressive plan
Induction · Trastuzumab + capecitabine + cisplatin (TOGA / KEYNOTE-811)
21-day cycles × Until progression / unacceptable toxicity (chemo backbone often capped at 6-8 cycles, trastuzumab continues mono)
Aggressive plan
Induction · Zolbetuximab + mFOLFOX6 (SPOTLIGHT) — 1L CLDN18.2-positive HER2-negative gastric/GEJ
14-day cycles × Until progression / unacceptable toxicity (oxaliplatin commonly capped at 8-12 cycles for cumulative neuropathy; zolbetuximab + 5-FU/LV maintenance continues)
Aggressive plan
Induction · Bemarituzumab + mFOLFOX6 (FORTITUDE-101) — 1L FGFR2b-overexpressing HER2-non-positive gastric/GEJ
14-day cycles × Until progression / unacceptable toxicity (oxaliplatin commonly capped at 8-12 cycles for cumulative neuropathy; bemarituzumab + 5-FU/LV maintenance continues; FORTITUDE-101 protocol allows oxaliplatin discontinuation per investigator with bemarituzumab + 5-FU/LV continued)
Standard plan
Induction · FOLFOX + Nivolumab
14-day cycles × Until progression / unacceptable toxicity (chemo backbone capped at ~12 cycles in some protocols; nivo continues mono until 2 years)
MDT brief
Discussion questions (5, 0 blocking)
OQ-LDH-CURRENT
What is the current LDH? Marker of tumor burden and transformation.
LDH is part of the prognostic indices of indolent lymphomas.
→ hematologist
OQ-BIOMARKER-CLDN18-2
What is the status of Claudin-18.2 expression (CLDN18.2) (BIO-CLDN18-2)? It is required by track(s): IND-GASTRIC-METASTATIC-1L-CLDN18-2-ZOLBETUXIMAB. Expected value: positive — ≥75% of tumor cells with 2+/3+ membranous staining (VENTANA CLDN18 (43-14A) RxDx).
A treatment-track biomarker requirement is missing from the patient profile; the MDT should verify the test result, method, specimen, and date before relying on this option.
→ pathologist
OQ-BIOMARKER-FGFR2B-IHC
What is the status of FGFR2b protein expression by IHC (membranous staining) (BIO-FGFR2B-IHC)? It is required by track(s): IND-GASTRIC-METASTATIC-1L-FGFR2B-BEMARITUZUMAB. Expected value: FGFR2b 2+/3+ membranous staining in ≥10% of tumor cells (FIGHT / FORTITUDE-101 threshold).
A treatment-track biomarker requirement is missing from the patient profile; the MDT should verify the test result, method, specimen, and date before relying on this option.
→ pathologist
OQ-BIOMARKER-HER2-SOLID
What is the status of HER2 status (solid tumors — gastric/GEJ/CRC scoring) (BIO-HER2-SOLID)? It is required by track(s): IND-GASTRIC-METASTATIC-1L-HER2-TOGA. Expected value: positive (IHC 3+ OR IHC 2+/ISH+).
A treatment-track biomarker requirement is missing from the patient profile; the MDT should verify the test result, method, specimen, and date before relying on this option.
→ pathologist
OQ-BIOMARKER-PDL1-CPS
What is the status of PD-L1 Combined Positive Score (CPS) (BIO-PDL1-CPS)? It is required by track(s): IND-GASTRIC-METASTATIC-1L-PDL1-CHEMO-ICI. Expected value: CPS ≥1.
A treatment-track biomarker requirement is missing from the patient profile; the MDT should verify the test result, method, specimen, and date before relying on this option.
→ pathologist
MDT talk tree (6 steps)
| # | Owner | Topic | Action |
|---|
| 1 | hematologist | Staging / disease burden | What is the current LDH? Marker of tumor burden and transformation. |
| 2 | pathologist | Biomarker status | What is the status of Claudin-18.2 expression (CLDN18.2) (BIO-CLDN18-2)? It is required by track(s): IND-GASTRIC-METASTATIC-1L-CLDN18-2-ZOLBETUXIMAB. Expected value: positive — ≥75% of tumor cells with 2+/3+ membranous staining (VENTANA CLDN18 (43-14A) RxDx). |
| 3 | pathologist | Biomarker status | What is the status of FGFR2b protein expression by IHC (membranous staining) (BIO-FGFR2B-IHC)? It is required by track(s): IND-GASTRIC-METASTATIC-1L-FGFR2B-BEMARITUZUMAB. Expected value: FGFR2b 2+/3+ membranous staining in ≥10% of tumor cells (FIGHT / FORTITUDE-101 threshold). |
| 4 | pathologist | Biomarker status | What is the status of HER2 status (solid tumors — gastric/GEJ/CRC scoring) (BIO-HER2-SOLID)? It is required by track(s): IND-GASTRIC-METASTATIC-1L-HER2-TOGA. Expected value: positive (IHC 3+ OR IHC 2+/ISH+). |
| 5 | pathologist | Biomarker status | What is the status of PD-L1 Combined Positive Score (CPS) (BIO-PDL1-CPS)? It is required by track(s): IND-GASTRIC-METASTATIC-1L-PDL1-CHEMO-ICI. Expected value: CPS ≥1. |
| 6 | clinical_pharmacist | Specialist review | Chemoimmunotherapy regimen — drug-drug interactions, dose adjustments, premedication. |
Skills (recommended) — for consideration (1)
Data quality
Usable with caveats. No critical default-track gap was found, but the MDT should review the listed caveats before final sign-off.
- Biomarker coverage: 0/4 known (0%), 4 missing, 0 default-track gaps
- Unevaluated RedFlags: RF-ACTIVE-AUTOIMMUNE-DISEASE-ICI-RISK, RF-BREAST-CDH1-LOBULAR-CANDIDATE, RF-CASCADE-FAP-FDR-POSITIVE, RF-CASCADE-LYNCH-FDR-POSITIVE, RF-CHRONIC-ATROPHIC-GASTRITIS-PREVENTION, RF-CHRONIC-H-PYLORI-MALIGNANCY-PREVENTION, RF-CRONKHITE-CANADA-CONFIRMED, RF-FAP-CONFIRMED-CARRIER, RF-FAP-FAMILY-HISTORY-SUSPICION, RF-GASTRIC-CLDN18-2-ACTIONABLE, RF-GASTRIC-EMERGENCY-BLEED-OBSTRUCTION, RF-GASTRIC-FRAILTY-AGE, RF-GASTRIC-HIGH-RISK-BIOLOGY, RF-GASTRIC-INFECTION-SCREENING, RF-GASTRIC-PDL1-CPS-1-PLUS, RF-GASTRIC-TRANSFORMATION-PROGRESSION, RF-HDGC-CDH1-CONFIRMED-CARRIER, RF-IATROGENIC-LONG-TERM-PPI-GASTRIC-NET-PREVENTION, RF-JPS-CONFIRMED-CARRIER, RF-LIFESTYLE-SALTY-PICKLED-DIET-GASTRIC-PREVENTION, RF-LYNCH-CONFIRMED-CARRIER, RF-LYNCH-FAMILY-HISTORY-SUSPICION, RF-OLIGOMET-DEFINITION, RF-PEUTZ-JEGHERS-CONFIRMED-CARRIER, RF-PEUTZ-JEGHERS-FAMILY-HISTORY-SUSPICION
| Missing biomarker | Label | MDT owner | Default track | Required by | Next action |
|---|
BIO-CLDN18-2 | Claudin-18.2 expression (CLDN18.2) | pathologist | no | IND-GASTRIC-METASTATIC-1L-CLDN18-2-ZOLBETUXIMAB | Verify result, method, specimen, and report date before sign-off. Expected/constraint: positive — ≥75% of tumor cells with 2+/3+ membranous staining (VENTANA CLDN18 (43-14A) RxDx) |
BIO-FGFR2B-IHC | FGFR2b protein expression by IHC (membranous staining) | pathologist | no | IND-GASTRIC-METASTATIC-1L-FGFR2B-BEMARITUZUMAB | Verify result, method, specimen, and report date before sign-off. Expected/constraint: FGFR2b 2+/3+ membranous staining in ≥10% of tumor cells (FIGHT / FORTITUDE-101 threshold) |
BIO-HER2-SOLID | HER2 status (solid tumors — gastric/GEJ/CRC scoring) | pathologist | no | IND-GASTRIC-METASTATIC-1L-HER2-TOGA | Verify result, method, specimen, and report date before sign-off. Expected/constraint: positive (IHC 3+ OR IHC 2+/ISH+) |
BIO-PDL1-CPS | PD-L1 Combined Positive Score (CPS) | pathologist | no | IND-GASTRIC-METASTATIC-1L-PDL1-CHEMO-ICI | Verify result, method, specimen, and report date before sign-off. Expected/constraint: CPS ≥1 |
Technical MDT skill metadata (1/16 activated in this plan)
All registered virtual specialists. ✓ — activated for this case; ○ — not activated (available for other clinical scenarios).
| Specialist | skill_id | Version | Last reviewed | Sign-offs | Domain |
|---|
| Cellular therapy specialist (CAR-T) | cellular_therapy_specialist | v0.1.0 | 2026-04-25 | 0 | cellular_therapy |
| Clinical pharmacist | clinical_pharmacist | v0.1.0 | 2026-04-25 | 0 | clinical_pharmacy |
| Hematologist / oncohematologist | hematologist | v0.1.0 | 2026-04-25 | 0 | hematology_oncology |
| Hematopathologist (lymphoma / leukemia / myeloma) | hematopathologist | v0.1.0 | 2026-04-25 | 0 | hematopathology |
| Infectious disease / hepatology | infectious_disease_hepatology | v0.1.0 | 2026-04-25 | 0 | infectious_diseases |
| Medical oncologist (solid-tumor chemotherapist) | medical_oncologist | v0.1.0 | 2026-04-25 | 0 | solid_oncology |
| Molecular geneticist / molecular oncologist | molecular_geneticist | v0.1.0 | 2026-04-25 | 0 | molecular_oncology |
| Palliative care | palliative_care | v0.1.0 | 2026-04-25 | 0 | palliative_care |
| Pathologist (general) | pathologist | v0.1.0 | 2026-04-25 | 0 | pathology |
| Primary care / family physician | primary_care | v0.1.0 | 2026-04-25 | 0 | primary_care |
| Psycho-oncologist | psychologist | v0.1.0 | 2026-04-25 | 0 | psychosocial |
| Radiation oncologist | radiation_oncologist | v0.1.0 | 2026-04-25 | 0 | radiation_oncology |
| Radiologist | radiologist | v0.1.0 | 2026-04-25 | 0 | diagnostic_imaging |
| Social worker / case manager | social_worker_case_manager | v0.1.0 | 2026-04-25 | 0 | psychosocial |
| Surgical oncologist | surgical_oncologist | v0.1.0 | 2026-04-25 | 0 | surgical_oncology |
| Transplant specialist (BMT) | transplant_specialist | v0.1.0 | 2026-04-25 | 0 | cellular_therapy |
Sources cited
- SRC-CHECKMATE-649-JANJIGIAN-2022: First-line nivolumab plus chemotherapy versus chemotherapy alone for advanced gastric, gastro-oesophageal junction, and oesophageal adenocarcinoma (CheckMate 649): a randomised, open-label, phase 3 trial (2021)
- SRC-ESMO-GASTRIC-2024: ESMO Gastric Cancer (2024)
- SRC-FORTITUDE-101: Bemarituzumab (BEMA) plus chemotherapy for advanced or metastatic FGFR2b-overexpressing gastric or gastroesophageal junction cancer (G/GEJC): FORTITUDE-101 phase 3 study results ()
- SRC-NCCN-GASTRIC-2025: NCCN Gastric Cancer (v.3.2025)
- SRC-OMEC-1-KROESE-2023: Definition, diagnosis and treatment of oligometastatic oesophagogastric cancer: A Delphi consensus study in Europe (2023)
- SRC-RENAISSANCE-AIO-FLOT5: The RENAISSANCE (AIO-FLOT5) trial: effect of chemotherapy alone vs. chemotherapy followed by surgical resection on survival and quality of life in patients with limited-metastatic adenocarcinoma of the stomach or esophagogastric junction - a phase III trial of the German AIO/CAO-V/CAOGI (2017)
Cited trials — current status
Recruiting status from ClinicalTrials.gov, refreshed via the per-NCT cache (`scripts/sync_ctgov_studies.py`).
Experimental options (clinical trials)
Third plan track — open-enrollment trials from ClinicalTrials.gov. Render-time metadata; engine selection is not affected by this block (CHARTER §8.3). Last synced: 2026-09-09.
| NCT | Title | Phase | Status | Sponsor | UA | Signals | Eligibility (excerpt) |
|---|
| NCT06572319 | Disitamab Vedotin Plus Trastuzumab in Patients With HER2 Positive GC/GEJ Patiens | PHASE1 / PHASE2 | RECRUITING | — | Small N (<50) Surrogate endpoint only Single country | |
| NCT07102901 | Safety and Efficacy of SHR2554 Combined With Other Antitumor Therapies in Gastric or Gastro-oesophageal Junction Adenocarcinoma | PHASE2 | RECRUITING | — | Surrogate endpoint only Single country | |
| NCT06902545 | A Study to Observe the Safety of VYLOY (Zolbetuximab) in People in South Korea With Gastric or Gastroesophageal Junction Cancer. | N/A | RECRUITING | — | Single country | |
| NCT06023758 | Phase 2 Trial of KN026+KN046±XELOX in HER2-positive Locally Advanced GC | PHASE2 | RECRUITING | — | Small N (<50) Single country | |
| NCT07221149 | A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Nivolumab in Combination With Chemotherapy in Participants With Previously Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma (ROSETTA Gastric-204) | PHASE2 / PHASE3 | RECRUITING | — | — | |
| NCT06999187 | A Study of DR-0202 in Patients With Locally Advanced or Metastatic, Relapsed or Refractory Carcinomas | PHASE1 | RECRUITING | — | Phase 1 only Single country | |
| NCT05269381 | Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumors | PHASE1 / PHASE2 | RECRUITING | — | Surrogate endpoint only Single country | |
| NCT06766578 | Clinical Study of Low-dose Interval Radiotherapy Combined With Tirelizumab and SOX Chemotherapy Neoadjuvant Therapy for Locally Advanced Gastric/Gastroesophageal Junction Adenocarcinoma | PHASE2 | RECRUITING | — | Small N (<50) Surrogate endpoint only Single country | |
| NCT06469944 | Substudy 06C: A Study of Investigational Agents With Pembrolizumab (MK-3475) and Chemotherapy in Participants With First-Line Locally Advanced Unresectable/Metastatic Gastroesophageal Adenocarcinoma (MK-3475-06C/KEYMAKER-U06) | PHASE1 / PHASE2 | RECRUITING | — | Surrogate endpoint only | |
| NCT05671822 | Ph1b/2 Study of the Safety and Efficacy of SHR-A1811 Combinations in Advanced HER2 Expression Gastric Cancer | PHASE2 | RECRUITING | — | Surrogate endpoint only Single country | |
Verify recruitment status directly with the trial site. ctgov data can lag behind current UA-site status.
Option availability in Ukraine
Per-track UA registration · NSZU · cost · access pathway. Render-time metadata; engine selection does not depend on these fields (CHARTER §8.3).
| Option | UA registration | NSZU | Cost orientation | Access pathway |
|---|
| Aggressive plan FLOT (REG-FLOT) | ✓ registered | ✓ covered | ₴-? — verify pathway | NSZU formulary |
| Aggressive plan Trastuzumab + capecitabine + cisplatin (TOGA / KEYNOTE-811) (REG-TRASTUZUMAB-CHEMO-TOGA) | ✓ registered | ✓ covered | ₴-? — verify pathway | NSZU formulary |
| Aggressive plan Zolbetuximab + mFOLFOX6 (SPOTLIGHT) — 1L CLDN18.2-positive HER2-negative gastric/GEJ (REG-ZOLBETUXIMAB-CHEMO) 1/4 component drug(s) not registered in Ukraine +1 | ✗ not registered | ✗ out-of-pocket | ₴-? — verify pathway | not recorded |
| Aggressive plan Bemarituzumab + mFOLFOX6 (FORTITUDE-101) — 1L FGFR2b-overexpressing HER2-non-positive gastric/GEJ (REG-BEMARITUZUMAB-MFOLFOX6) 1/4 component drug(s) not registered in Ukraine +1 | ✗ not registered | ✗ out-of-pocket | ₴-? — verify pathway | not recorded |
| Standard plan FOLFOX + Nivolumab (REG-FOLFOX-NIVO) | ✓ registered | ✓ covered | ₴-? — verify pathway | NSZU formulary |
| Trial · NCT06572319 Disitamab Vedotin Plus Trastuzumab in Patients With HER2 Positive GC/GEJ Patiens No UA site listed — international referral required | — unknown | — unknown | self-pay: ₴0/course | Trial sponsor |
| Trial · NCT07102901 Safety and Efficacy of SHR2554 Combined With Other Antitumor Therapies in Gastric or Gastro-oesophageal Junction Adenocarcinoma No UA site listed — international referral required | — unknown | — unknown | self-pay: ₴0/course | Trial sponsor |
| Trial · NCT06902545 A Study to Observe the Safety of VYLOY (Zolbetuximab) in People in South Korea With Gastric or Gastroesophageal Junction Cancer. No UA site listed — international referral required | — unknown | — unknown | self-pay: ₴0/course | Trial sponsor |
| Trial · NCT06023758 Phase 2 Trial of KN026+KN046±XELOX in HER2-positive Locally Advanced GC No UA site listed — international referral required | — unknown | — unknown | self-pay: ₴0/course | Trial sponsor |
| Trial · NCT07221149 A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Nivolumab in Combination With Chemotherapy in Participants With Previously Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma (ROSETTA Gastric-204) No UA site listed — international referral required | — unknown | — unknown | self-pay: ₴0/course | Trial sponsor |
| Trial · NCT06999187 A Study of DR-0202 in Patients With Locally Advanced or Metastatic, Relapsed or Refractory Carcinomas No UA site listed — international referral required | — unknown | — unknown | self-pay: ₴0/course | Trial sponsor |
| Trial · NCT05269381 Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumors No UA site listed — international referral required | — unknown | — unknown | self-pay: ₴0/course | Trial sponsor |
| Trial · NCT06766578 Clinical Study of Low-dose Interval Radiotherapy Combined With Tirelizumab and SOX Chemotherapy Neoadjuvant Therapy for Locally Advanced Gastric/Gastroesophageal Junction Adenocarcinoma No UA site listed — international referral required | — unknown | — unknown | self-pay: ₴0/course | Trial sponsor |
| Trial · NCT06469944 Substudy 06C: A Study of Investigational Agents With Pembrolizumab (MK-3475) and Chemotherapy in Participants With First-Line Locally Advanced Unresectable/Metastatic Gastroesophageal Adenocarcinoma (MK-3475-06C/KEYMAKER-U06) No UA site listed — international referral required | — unknown | — unknown | self-pay: ₴0/course | Trial sponsor |
| Trial · NCT05671822 Ph1b/2 Study of the Safety and Efficacy of SHR-A1811 Combinations in Advanced HER2 Expression Gastric Cancer No UA site listed — international referral required | — unknown | — unknown | self-pay: ₴0/course | Trial sponsor |
Cost information is orientation. Verify with a specific pharmacy / foundation / trial site. Status updated: 2026-09-09.