OpenOnco · Treatment Plan

Treatment plan — T-Lymphoblastic Leukemia/Lymphoma

PLAN-T-LBL-MEDIASTINAL-001-V1 · v1 · 2026-07-26

Patient

T-LBL-MEDIASTINAL-001 · Algorithm: ALGO-T-ALL-1L

DiagnosisT-Lymphoblastic Leukemia/Lymphoma

MOH / ICD-10C91.0

ICD-O-39837/3

Clinical significance of mutations (ESCAT)

Tumor-board context — the engine does not use these tiers to rank tracks

Biomarker	Variant	ESCAT	Evidence	Clinical significance	Drugs	Sources
No clinically actionable variants matched in this profile.

Primary current-line option

Standard plan

★ DEFAULT

Indication

IND-T-ALL-1L-HYPER-CVAD

Regimen

Hyper-CVAD + Rituximab (CD20+) — alternating courses A/B, 8 cycles total

Drugs + NSZU

Alternating block A — block A (Hyper-CVAD): cyclophosphamide + vincristine + doxorubicin + dexamethasone — cycles 1, 3, 5, 7; with rituximab for CD20+ (cycles 1-4) and IT-CNS prophylaxis

Cyclophosphamide (DRUG-CYCLOPHOSPHAMIDE) 300 mg/m² q12h × 6 doses · IV days 1-3 (Course A only) · IV ⚠ NSZU — not for this indication
Vincristine (DRUG-VINCRISTINE) 2 mg flat dose · IV days 4 + 11 (Course A only) · IV ⚠ NSZU — not for this indication
Doxorubicin (DRUG-DOXORUBICIN) 50 mg/m² · IV day 4 (Course A only) · IV ⚠ NSZU — not for this indication
Dexamethasone (DRUG-DEXAMETHASONE) 40 mg · PO/IV days 1-4 + 11-14 (Course A only) · PO ⚠ NSZU — not for this indication
Rituximab (DRUG-RITUXIMAB) 375 mg/m² · IV days 1 + 11 (cycles 1-4 для CD20+ only) · IV ⚠ NSZU — not for this indication
Methotrexate (DRUG-METHOTREXATE) 12 mg IT · IT day 2 each cycle · IT ⚠ NSZU — not for this indication
Cytarabine (DRUG-CYTARABINE) 100 mg IT · IT day 8 each cycle · IT ⚠ NSZU — not for this indication

Alternating block B — block B (MA): high-dose methotrexate + HD-cytarabine — cycles 2, 4, 6, 8; with rituximab for CD20+ (cycles 1-4) and IT-CNS prophylaxis

Methotrexate (DRUG-METHOTREXATE) 1 g/m² · IV 24h infusion day 1 (Course B only); leucovorin rescue · IV ⚠ NSZU — not for this indication
Cytarabine (DRUG-CYTARABINE) 3 g/m² q12h × 4 doses · IV days 2-3 (Course B only) · IV ⚠ NSZU — not for this indication
Rituximab (DRUG-RITUXIMAB) 375 mg/m² · IV days 1 + 11 (cycles 1-4 для CD20+ only) · IV ⚠ NSZU — not for this indication
Methotrexate (DRUG-METHOTREXATE) 12 mg IT · IT day 2 each cycle · IT ⚠ NSZU — not for this indication
Cytarabine (DRUG-CYTARABINE) 100 mg IT · IT day 8 each cycle · IT ⚠ NSZU — not for this indication

Supportive care

SUP-PJP-PROPHYLAXIS, SUP-HSV-PROPHYLAXIS, SUP-TLS-PROPHYLAXIS, SUP-GCSF-NEUTROPENIA, SUP-ANTIEMETIC-PREMED

Hard contraindications

CI-LVEF-LOW-FOR-ANTHRACYCLINE

Reason

Primary current-line option selected by ALGO-T-ALL-1L at step 1.

Pre-treatment investigations

Investigations before treatment start · critical / standard / desired · merged across tracks

ID	Name	Priority	Category	Where to order	Needed for
TEST-BM-ASPIRATE	Bone Marrow Aspirate	Critical	histology	—	all tracks
TEST-BM-TREPHINE	Bone Marrow Trephine	Critical	histology	—	all tracks
TEST-CBC	Complete Blood Count with Differential	Critical	lab	—	all tracks
TEST-CECT-CAP	CECT chest/abdomen/pelvis	Critical	imaging	—	all tracks
TEST-CMP	Comprehensive Metabolic Panel	Critical	lab	—	all tracks
TEST-COAG-PANEL	Coagulation Panel	Critical	lab	—	all tracks
TEST-FISH-PANEL	FISH (Fluorescence In Situ Hybridization)	Critical	genomic	CSD Lab ✓ (code TBC)	all tracks
TEST-FLOW-CYTOMETRY	Flow Cytometry	Critical	histology	CSD Lab ✓ (code TBC)	all tracks
TEST-HBV-SEROLOGY	Hepatitis B Serology Panel (HBsAg, anti-HBc total, anti-HBs)	Critical	lab	—	all tracks
TEST-HIV-SEROLOGY	HIV Antibody/Antigen	Critical	lab	—	all tracks
TEST-KARYOTYPE	Karyotype	Critical	genomic	CSD Lab ✓ (code TBC)	all tracks
TEST-LDH	Lactate Dehydrogenase	Critical	lab	—	all tracks
TEST-LFT	Liver Function Tests (ALT, AST, bilirubin, ALP, GGT, albumin)	Critical	lab	—	all tracks
TEST-PREGNANCY	Beta-HCG	Critical	lab	—	all tracks
TEST-CSF-CYTOLOGY-FLOW	CSF cytology + flow cytometry	Standard	pathology	CSD Lab ✓ (code TBC)	all tracks
TEST-ECHO	Echocardiography	Standard	imaging	—	all tracks
TEST-PET-CT	FDG PET/CT (whole body)	Standard	imaging	—	all tracks
TEST-URIC-ACID	Serum Uric Acid	Standard	lab	—	all tracks
TEST-NGS-LYMPHOID-PANEL	Lymphoid NGS Panel	Desired	genomic	CSD Lab ✓ (code TBC)	all tracks

What NOT to do

Explicit prohibitive rules, each grounded in a regimen / supportive care / contraindication entity

Standard plan (IND-T-ALL-1L-HYPER-CVAD)

Do not skip CNS prophylaxis (IT MTX/cytarabine + HD-MTX).
Do not disregard mediastinal mass airway compromise — pre-induction steroids + ICU readiness.
Do not administer vincristine intrathecally — fatal.
Do not give rituximab — CD20- not a target.
Do not skip TLS prophylaxis in hyperleukocytosis.

Timeline

Treatment timeline — derived from regimen + monitoring schedule

Standard plan

Induction · Hyper-CVAD + Rituximab (CD20+) — alternating courses A/B, 8 cycles total

21-day cycles × 8 alternating cycles (A/B/A/B/A/B/A/B); maintenance POMP × 30 months Ph-, або continuous TKI Ph+

MDT brief

Data quality

Usable with caveats. No critical default-track gap was found, but the MDT should review the listed caveats before final sign-off.

Biomarker coverage: 0/0 known (100%), 0 missing, 0 default-track gaps
Unevaluated RedFlags: RF-RUNX1-CONFIRMED-CARRIER, RF-T-ALL-CNS-LEUKEMIA, RF-T-ALL-EMERGENCY-TLS-LEUKOSTASIS, RF-T-ALL-FRAILTY-AGE, RF-T-ALL-HIGH-RISK-BIOLOGY, RF-T-ALL-INFECTION-SCREENING, RF-T-ALL-MEDIASTINAL-AIRWAY, RF-T-ALL-ORGAN-DYSFUNCTION, RF-T-ALL-TRANSFORMATION-PROGRESSION

Technical MDT skill metadata (0/16 activated in this plan)

All registered virtual specialists. ✓ — activated for this case; ○ — not activated (available for other clinical scenarios).

Specialist	skill_id	Version	Last reviewed	Domain
Cellular therapy specialist (CAR-T)	`cellular_therapy_specialist`	v0.1.0	2026-04-25	cellular_therapy
Clinical pharmacist	`clinical_pharmacist`	v0.1.0	2026-04-25	clinical_pharmacy
Hematologist / oncohematologist	`hematologist`	v0.1.0	2026-04-25	hematology_oncology
Hematopathologist (lymphoma / leukemia / myeloma)	`hematopathologist`	v0.1.0	2026-04-25	hematopathology
Infectious disease / hepatology	`infectious_disease_hepatology`	v0.1.0	2026-04-25	infectious_diseases
Medical oncologist (solid-tumor chemotherapist)	`medical_oncologist`	v0.1.0	2026-04-25	solid_oncology
Molecular geneticist / molecular oncologist	`molecular_geneticist`	v0.1.0	2026-04-25	molecular_oncology
Palliative care	`palliative_care`	v0.1.0	2026-04-25	palliative_care
Pathologist (general)	`pathologist`	v0.1.0	2026-04-25	pathology
Primary care / family physician	`primary_care`	v0.1.0	2026-04-25	primary_care
Psycho-oncologist	`psychologist`	v0.1.0	2026-04-25	psychosocial
Radiation oncologist	`radiation_oncologist`	v0.1.0	2026-04-25	radiation_oncology
Radiologist	`radiologist`	v0.1.0	2026-04-25	diagnostic_imaging
Social worker / case manager	`social_worker_case_manager`	v0.1.0	2026-04-25	psychosocial
Surgical oncologist	`surgical_oncologist`	v0.1.0	2026-04-25	surgical_oncology
Transplant specialist (BMT)	`transplant_specialist`	v0.1.0	2026-04-25	cellular_therapy

Sources cited

SRC-NCCN-BCELL-2025: NCCN Clinical Practice Guidelines in Oncology: B-Cell Lymphomas (v.2.2025)

Experimental options (clinical trials)

Third plan track — open-enrollment trials from ClinicalTrials.gov. Render-time metadata; engine selection is not affected by this block (CHARTER §8.3). Last synced: 2026-07-26.

NCT	Title	Phase	Status	Sponsor	UA	Signals
NCT06904066	Autologous T Cells Transduced With Retroviral Vectors Expressing TCRs for Participant-specific Neoantigens in Patients With Hematologic Malignancies	PHASE1	RECRUITING	National Cancer Institute (NCI)	—	Phase 1 only Single country
NCT02727803	Personalized NK Cell Therapy in CBT	PHASE2	RECRUITING	M.D. Anderson Cancer Center	—	Surrogate endpoint only Single country
NCT05281809	Local Manufacture of CAR T-Cell Products for the Treatment of B-Cell Lymphoma and B-Acute Lymphoblastic Leukemia	PHASE2	RECRUITING	John Lister	—	Small N (<50) Single country
NCT07513129	Venetoclax, Dexamethasone, Bortezomib, and Daratumumab For The Treatment Of Adolescent And Young Adults With Relapsed Or Refractory T-Cell Acute Lymphoblastic Leukemia And T-cell Acute Lymphoblastic Lymphoma	PHASE1	RECRUITING	M.D. Anderson Cancer Center	—	Phase 1 only Small N (<50) Single country
NCT07479927	Telematic Cognitive Training and Mindfulness in Pediatric Patients After CAR-T Cell Therapy, Single Hematopoietic Allogeneic Transplant or Chemotherapy	NA	RECRUITING	Hospital Universitario La Paz	—	Small N (<50) Single country
NCT07532525	Pomalidomide After CAR T-cell Therapy for the Treatment of Relapsed or Refractory CD19+ B-cell Leukemia or Lymphoma	PHASE1	RECRUITING	University of Michigan Rogel Cancer Center	—	Phase 1 only Small N (<50) Single country
NCT04888741	Methods of T Cell Depletion Trial (MoTD)	PHASE2	RECRUITING	University of Birmingham	—	Single country
NCT07366801	Co-infusion of Treg-enriched Donor Lymphocytes With CD3-depleted Hematopoietic Stem Cell Graft to Prevent Graft-versus Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation Among Children With Hematologic Malignancies	PHASE2 / PHASE3	RECRUITING	Federal Research Institute of Pediatric Hematology, Oncology and Immunology	—	Single country
NCT05210907	Clinical Study of Hospital-manufactured CD19 CAR-T in Children and Adolescents With Acute Lymphoblastic Leukemia	PHASE1	RECRUITING	Seoul National University Hospital	—	Phase 1 only Small N (<50) Single country
NCT07575919	Targeted CD22/CD19 CAR-T Therapy for Consolidation in Standard-Risk B-ALL	PHASE1 / PHASE2	RECRUITING	Liping Dou	—	Small N (<50) Single country

Verify recruitment status directly with the trial site. ctgov data can lag behind current UA-site status.

Option availability in Ukraine

Per-track UA registration · NSZU · cost · access pathway. Render-time metadata; engine selection does not depend on these fields (CHARTER §8.3).

Option	UA registration	NSZU	Cost orientation	Access pathway
Standard plan Hyper-CVAD + Rituximab (CD20+) — alternating courses A/B, 8 cycles total (REG-HYPER-CVAD-R)	✓ registered	✓ covered	₴-? — verify pathway	NSZU formulary
Trial · NCT06904066 Autologous T Cells Transduced With Retroviral Vectors Expressing TCRs for Participant-specific Neoantigens in Patients With Hematologic Malignancies No UA site listed — international referral required	— unknown	— unknown	self-pay: ₴0/course	Trial sponsor
Trial · NCT02727803 Personalized NK Cell Therapy in CBT No UA site listed — international referral required	— unknown	— unknown	self-pay: ₴0/course	Trial sponsor
Trial · NCT05281809 Local Manufacture of CAR T-Cell Products for the Treatment of B-Cell Lymphoma and B-Acute Lymphoblastic Leukemia No UA site listed — international referral required	— unknown	— unknown	self-pay: ₴0/course	Trial sponsor
Trial · NCT07513129 Venetoclax, Dexamethasone, Bortezomib, and Daratumumab For The Treatment Of Adolescent And Young Adults With Relapsed Or Refractory T-Cell Acute Lymphoblastic Leukemia And T-cell Acute Lymphoblastic Lymphoma No UA site listed — international referral required	— unknown	— unknown	self-pay: ₴0/course	Trial sponsor
Trial · NCT07479927 Telematic Cognitive Training and Mindfulness in Pediatric Patients After CAR-T Cell Therapy, Single Hematopoietic Allogeneic Transplant or Chemotherapy No UA site listed — international referral required	— unknown	— unknown	self-pay: ₴0/course	Trial sponsor
Trial · NCT07532525 Pomalidomide After CAR T-cell Therapy for the Treatment of Relapsed or Refractory CD19+ B-cell Leukemia or Lymphoma No UA site listed — international referral required	— unknown	— unknown	self-pay: ₴0/course	Trial sponsor
Trial · NCT04888741 Methods of T Cell Depletion Trial (MoTD) No UA site listed — international referral required	— unknown	— unknown	self-pay: ₴0/course	Trial sponsor
Trial · NCT07366801 Co-infusion of Treg-enriched Donor Lymphocytes With CD3-depleted Hematopoietic Stem Cell Graft to Prevent Graft-versus Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation Among Children With Hematologic Malignancies No UA site listed — international referral required	— unknown	— unknown	self-pay: ₴0/course	Trial sponsor
Trial · NCT05210907 Clinical Study of Hospital-manufactured CD19 CAR-T in Children and Adolescents With Acute Lymphoblastic Leukemia No UA site listed — international referral required	— unknown	— unknown	self-pay: ₴0/course	Trial sponsor
Trial · NCT07575919 Targeted CD22/CD19 CAR-T Therapy for Consolidation in Standard-Risk B-ALL No UA site listed — international referral required	— unknown	— unknown	self-pay: ₴0/course	Trial sponsor

Cost information is orientation. Verify with a specific pharmacy / foundation / trial site. Status updated: 2026-07-26.

plan_id: PLAN-T-LBL-MEDIASTINAL-001-V1 | version: 1 | generated: 2026-07-26T09:28:48.275660+00:00

Per FDA non-device CDS positioning (CHARTER §15): Outpatient oncology treatment planning to support tumor-board discussion. Not a medical device; not for autonomous clinical decision-making.

Per FDA non-device CDS positioning (CHARTER §15): Both treatment options below are presented for review. The engine's selection of a 'recommended' default does not constitute a clinical decision. Final treatment selection requires HCP judgment incorporating information not available to the system.

This document is an informational resource supporting tumor-board discussion (per CHARTER §11). It is not a system that makes clinical decisions. Every recommendation must be verified by the treating physician.