Heavy alcohol use — ≥3 standard drinks per day in men, ≥2 standard drinks per day in wome...

Детермінований перегляд YAML-сутності з джерельної бази. Клінічний авторитет лишається за вказаними source ID та статусом клінічного sign-off.

ID	`RF-UNIVERSAL-HEAVY-ALCOHOL-MULTI-CANCER`
Тип	Тривожна ознака
Статус	переглянуто 2026-05-18 \| очікує клінічного підпису
Хвороби	Не вказано
Джерела	`SRC-IARC-100E-ALCOHOL` `SRC-WCRF-AICR-CUP-2018`

Походження тривожної ознаки

Визначення	Heavy alcohol use — ≥3 standard drinks per day in men, ≥2 standard drinks per day in women (one US-standard drink = 14 g pure ethanol). IARC Monograph 100E (2012) and the IARC Working Group on Alcoholic Beverages and Ethanol classify alcoholic beverages as Group 1 carcinogen with sufficient evidence for ≥7 cancer types: oral cavity, pharynx, larynx, oesophagus (squamous cell), liver (HCC), colorectum, and female breast. WCRF / AICR Continuous Update Project (2018) adds gastric cardia and probable evidence for pancreas. Dose-response is supra-linear for upper-aerodigestive cancers (multiplicative synergy with tobacco — combined heavy use 10-100× baseline risk for oral / oesophageal cancers) and approximately log-linear for breast (HR ~1.05-1.10 per drink/day). No safe lower threshold for cancer risk has been established (ESC 2018, ICRP 2020). Universal RedFlag (relevant_diseases ["*"]) —...
Клінічний напрям	investigate
Категорія	other

Логіка спрацьовування

{
  "any_of": [
    {
      "finding": "heavy_alcohol_use_documented",
      "value": true
    }
  ],
  "type": "composite_score"
}

Нотатки

Pre-triage universal RedFlag — heavy alcohol use (≥3 drinks/d men, ≥2 drinks/d women) per IARC 100E 7-cancer cluster. Authoring intent: cessation counseling (motivational interviewing + AUD-pharmacotherapy per AUDIT-C / DSM-5 severity stratification) + alcohol-related-cancer screening adjustment (HCC US+AFP q6mo if cirrhosis; UADT low-threshold; breast / CRC per age-and-modality standards). With relevant_diseases=["*"], engine does NOT attach Indication tracks via prevention path (plan.py:297 excludes "*") — universal Indications anchored to DIS-HCC are documentation / sidecar candidates pending future engine extension. STUB pending two-Clinical-Co-Lead signoff per CHARTER §6.1 dev-mode.

Де використовується

Indications

IND-UNIVERSAL-HEAVY-ALCOHOL-PREVENTION-BRIEF-INTERVENTION - IND-UNIVERSAL-HEAVY-ALCOHOL-PREVENTION-BRIEF-INTERVENTION
IND-UNIVERSAL-HEAVY-ALCOHOL-PREVENTION-CESSATION-SCREENING - IND-UNIVERSAL-HEAVY-ALCOHOL-PREVENTION-CESSATION-SCREENING