Documented historical occupational exposure as a painter — typical high-risk roles includ...

Детермінований перегляд YAML-сутності з джерельної бази. Клінічний авторитет лишається за вказаними source ID та статусом клінічного sign-off.

ID	`RF-OCC-PAINTERS-PREVENTION`
Тип	Тривожна ознака
Статус	переглянуто 2026-05-18 \| очікує клінічного підпису
Хвороби	`DIS-AML` `DIS-NSCLC` `DIS-SCLC` `DIS-UROTHELIAL`
Джерела	`SRC-NCCN-BCELL-2025` `SRC-NCCN-NSCLC-2025`

Походження тривожної ознаки

Визначення	Documented historical occupational exposure as a painter — typical high-risk roles include industrial / construction painters, ship painters, automotive painters, and tradespeople with ≥10 years continuous painting work — in an individual without a current paint-occupation-associated malignancy diagnosis. IARC classifies "Occupational exposure as a painter" as a Group 1 carcinogen (Monograph 100F, 2012) based on the heterogeneous solvent / pigment / binder mixture historically encountered (benzene-containing solvents, toluene, xylene, lead-based and chromium-based pigments, asbestos fillers in older formulations). Cancer endpoints with established occupational excess: lung cancer (consistent across cohorts), bladder cancer (consistent), childhood leukemia in offspring of exposed parents (perinatal-exposure window), and adult AML / NHL (less consistent but elevated). Latency 10-40 years....
Клінічний напрям	investigate
Категорія	other

Логіка спрацьовування

{
  "any_of": [
    {
      "finding": "occupational_painter_exposure_documented",
      "value": true
    },
    {
      "finding": "occupational_painter_years_ge_10",
      "value": true
    }
  ],
  "type": "lab_value"
}

Нотатки

Prevention-persona RedFlag — v0.3 occupational batch-2 pilot. Fires when patient profile carries documented ≥10 years occupational exposure as a painter AND no confirmed paint-occupation-attributable malignancy diagnosis. Engine routes to 2-track PreventionPlan: (a) IND-OCC-PAINTERS-PREVENTION-INTENSIFIED-SURVEILLANCE (standard) — risk-adjusted annual LDCT chest if smoker-eligible per USPSTF; urinalysis q1-2y for bladder surveillance; CBC q1y for hematologic surveillance; smoking-cessation counseling. (b) IND-OCC-PAINTERS-PREVENTION-OBSERVATION (surveillance) — routine general-population USPSTF screening only; patient declines intensified multi-modality surveillance. Trigger findings are computed booleans from occupational-history intake at the patient-profile layer. Evidence base: IARC Monograph 100F (2012); Guha et al. 2010 (pooled painter-cohort meta-analysis — lung-cancer RR ~1.35, bladder-cancer RR ~1.25). Heterogeneity of historical paint formulations (benzene-containing solvents, lead chromate pigments, asbestos fillers) drives multi-organ risk pattern. Sources TODO: IARC Monograph 100F (2012) as a new SRC entity. v0.3 source-authoring backlog. STUB pending two-Clinical-Co-...

Де використовується

Indications

IND-OCC-PAINTERS-PREVENTION-INTENSIFIED-SURVEILLANCE - IND-OCC-PAINTERS-PREVENTION-INTENSIFIED-SURVEILLANCE
IND-OCC-PAINTERS-PREVENTION-OBSERVATION - IND-OCC-PAINTERS-PREVENTION-OBSERVATION