Regular processed-meat consumption ≥50 g/day per WCRF/IARC threshold. IARC Monograph 114...

Детермінований перегляд YAML-сутності з джерельної бази. Клінічний авторитет лишається за вказаними source ID та статусом клінічного sign-off.

ID	`RF-LIFESTYLE-PROCESSED-MEAT-PREVENTION`
Тип	Тривожна ознака
Статус	переглянуто 2026-05-18 \| очікує клінічного підпису
Хвороби	`DIS-CRC`
Джерела	`SRC-NCCN-BCELL-2025` `SRC-NCCN-COLON-2025`

Походження тривожної ознаки

Визначення	Regular processed-meat consumption ≥50 g/day per WCRF/IARC threshold. IARC Monograph 114 (2015) classified processed meat as Group 1 carcinogen for colorectal cancer (sufficient evidence). Each 50 g/day of processed meat increases CRC risk by ~18% (meta-analyzed RR ~1.18; WCRF/AICR convincing-evidence rating). Processed meat = sausages, ham, bacon, salami, cured/smoked/salted/preserved meat. Red meat (Group 2A per IARC, probable carcinogen) is a separate but overlapping concern — threshold ≥500 g/week for red meat. Mechanisms: N-nitroso compounds, heterocyclic amines, polycyclic aromatic hydrocarbons, heme iron. Prevention-persona RedFlag (§20 v0.3 lifestyle pilot).
Клінічний напрям	investigate
Категорія	other

Логіка спрацьовування

{
  "any_of": [
    {
      "finding": "processed_meat_intake_ge_50g_per_day",
      "value": true
    },
    {
      "finding": "red_meat_intake_ge_500g_per_week",
      "value": true
    }
  ],
  "type": "lab_value"
}

Нотатки

Prevention-persona RedFlag for processed-meat consumption ≥50g/day. WCRF/AICR convincing evidence + IARC Group 1 classification for CRC. Effect size modest individually but population-attributable fraction non-trivial. Engine routes to PreventionPlan recommending dietary counseling + CRC screening per USPSTF. STUB pending two-Clinical-Co-Lead signoff per CHARTER §6.1 dev-mode.

Де використовується

Indications

IND-LIFESTYLE-PROCESSED-MEAT-PREVENTION-DIETARY - IND-LIFESTYLE-PROCESSED-MEAT-PREVENTION-DIETARY
IND-LIFESTYLE-PROCESSED-MEAT-PREVENTION-OBSERVATION - IND-LIFESTYLE-PROCESSED-MEAT-PREVENTION-OBSERVATION

Тривожна ознака

RF-LIFESTYLE-HIGH-RED-MEAT-CRC-PREVENTION - Habitual high red-meat consumption (≥500 g/week of cooked unprocessed red meat — beef, la...