Phenoxybenzamine
Детермінований перегляд YAML-сутності з джерельної бази. Клінічний авторитет лишається за вказаними source ID та статусом клінічного sign-off.
| ID | DRUG-PHENOXYBENZAMINE |
|---|---|
| Тип | Препарат |
| Синоніми | Dibenzylinenon-selective irreversible alpha blockerФеноксибензамін |
| Статус | переглянуто 2026-07-11 | очікує клінічного підпису |
| Хвороби | DIS-PHEOCHROMOCYTOMA |
| Джерела | SRC-ENDOCRINE-SOCIETY-PPGL-2014 SRC-NCCN-NET-2025 |
Дані про препарат
| Клас | Non-selective, irreversible alpha-1/alpha-2 adrenergic receptor antagonist |
|---|---|
| Механізм дії | Covalently and irreversibly binds alpha-1 and alpha-2 adrenergic receptors, producing a long-acting, non-competitive blockade of catecholamine-mediated vasoconstriction. In pheochromocytoma / paraganglioma (PPGL), preoperative alpha-blockade with phenoxybenzamine (or a selective alpha-1 blocker such as doxazosin) is mandatory before surgery to prevent an intraoperative hypertensive crisis from catecholamine release during tumor manipulation (Endocrine Society 2014 PPGL guideline). Alpha-2 blockade component can cause reflex tachycardia and orthostatic hypotension, which is more pronounced than with selective alpha-1 agents. |
| Типове дозування | Starting dose typically 10 mg PO BID, titrated upward in 10-20 mg/day increments every few days to achieve blood-pressure normalization and resolution of orthostatic/paroxysmal symptoms, per Endocrine Society 2014 PPGL guideline (SRC-ENDOCRINE-SOCIETY-PPGL-2014); usual preoperative course runs roughly one to two weeks before surgery to allow adequate, sustained alpha-blockade and intravascular volume re-expansion. Exact target BP/HR thresholds and final maintenance dose are individualized by the treating team and are NOT fixed numeric values in this stub -- see RF-PHEO-INADEQUATE-ALPHA-BLOCKADE for the hard sequencing gate this drug exists to satisfy. |
| Зареєстровано в Україні | False |
| Відшкодовується НСЗУ | False |
| Остання перевірка для України | 2026-07-11 |
Нотатки
Historically the guideline-preferred agent for preoperative PPGL alpha-blockade because its irreversible, long-acting blockade is harder to overcome with catecholamine surge during tumor handling; doxazosin (selective, reversible alpha-1 blocker; see DRUG-DOXAZOSIN) is a widely used, more available and better-tolerated alternative with less reflex tachycardia -- choice between the two is per local practice/availability, not modelled as a KB-level preference. STUB pending clinical co-lead signoff (CHARTER §6.1, dev-mode-exempted).
Де використовується
Regimens
REG-ALPHA-BLOCKADE-PREOP-PHEO- Preoperative alpha-adrenergic blockade (phenoxybenzamine, before pheochromocytoma/paragan...
Препарат
DRUG-DOXAZOSIN- Doxazosin