Nicotine gum (NRT)
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| ID | DRUG-NICOTINE-GUM |
|---|---|
| Тип | Препарат |
| Синоніми | Habitrol gumNRT gumNicorette gumNicotine gumNicotine polacrilexNicotine replacement therapy — gumNicotinell gumNiquitin gumНікотинова жувальна гумка (NRT) |
| Статус | переглянуто 2026-05-18 | очікує клінічного підпису |
| Хвороби | Не вказано |
| Джерела | SRC-IARC-100A-TOBACCO-SMOKING SRC-USPSTF-LUNG-LDCT-2021 |
Дані про препарат
| Клас | Nicotine replacement therapy (NRT) — buccal short-acting |
|---|---|
| Механізм дії | Nicotine polacrilex resin releases nicotine slowly across the oral mucosa during intermittent chewing (chew-and-park technique). Peak plasma concentration ~20-30 min, ~1/3 to 1/2 of inhaled cigarette peak, relieving acute craving and withdrawal while avoiding the rapid arterial pulse of smoking that drives addiction. Cancer-prevention rationale: tobacco cessation is the highest- impact modifiable intervention against lung, head-and-neck, bladder, esophageal, pancreatic, cervical, kidney, AML, and other tobacco-attributable cancers (IARC Monograph 100E — Personal Habits and Indoor Combustions). NRT roughly doubles 6-month abstinence vs. placebo (Cochrane); combining a patch (long-acting baseline) with a short-acting form (gum or lozenge) PRN improves quit rates over monotherapy. USPSTF Grade A for adult tobacco-cessation pharmacotherapy. |
| Типове дозування | Strength selection by time-to-first-cigarette (TTFC): - TTFC ≤30 min OR ≥25 cig/d: start 4 mg gum - TTFC >30 min OR <25 cig/d: start 2 mg gum Cadence (10-12 week course typical): - Weeks 1-6: 1 piece every 1-2 h (≥9 pieces/day at start) - Weeks 7-9: 1 piece every 2-4 h - Weeks 10-12: 1 piece every 4-8 h Maximum 24 pieces/day. CHEW-AND-PARK technique: chew slowly until tingling/peppery taste, then park between cheek and gum, resume chewing when taste fades; ~30 min per piece. Avoid food/drink (especially acidic — coffee, juice, soft drinks) for 15 min before/during use — acidic pH reduces buccal nicotine absorption. Combination NRT (patch baseline + PRN gum) preferred over monotherapy. |
| Зареєстровано в Україні | True |
| Відшкодовується НСЗУ | False |
| Остання перевірка для України | 2026-05-18 |
Нотатки
STUB — v0.2 prevention-workstream authoring (batch 2); pending two- Clinical-Co-Lead signoff per CHARTER §6.1 dev-mode. First-line tobacco-cessation NRT (USPSTF Grade A for adults; insufficient evidence in pregnancy). PARTNER to DRUG-NICOTINE-PATCH (long-acting baseline) and DRUG-NICOTINE-LOZENGE (alternative short-acting). Cochrane Stead 2012 meta-analysis: any NRT vs. placebo OR ~1.6 for 6-month abstinence; combination NRT OR ~1.3 vs. NRT monotherapy. Patient selection: prefer LOZENGE over gum if dental issues, TMJ disease, or dentures. CHEW-AND-PARK technique training is critical for efficacy — gum is more user-error-sensitive than lozenge or patch. Primary RCTs (e.g., Garvey 2000, Tonnesen 1988) not yet ingested as standalone SRC-* entities; cited sources cover the tobacco-cancer causal relationship (IARC-100A) and the lung-cancer screening context where cessation is integrated (USPSTF-LUNG-LDCT). Engine should surface NRT options when prevention pilots flag current tobacco use; specific-form choice belongs to patient/clinician.
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