Workup steps (7)

• 1histology Cystoscopy with biopsy / TURBT
  Direct visualization of bladder mucosa, biopsy of suspicious lesions, and transurethral resection of bladder tumor (TURBT) for diagnosis, staging (muscle-invasive vs non-muscle-invasive), and initial management.
• 2lab Voided urine cytology (Paris System)
  Adjunct to cystoscopy for hematuria workup; sensitive for high-grade urothelial carcinoma and CIS, low sensitivity for low-grade tumors.
• 3imaging CT urography (multi-phase with excretory phase)
  Evaluation of upper urinary tract for hematuria workup; detects upper-tract urothelial carcinoma (UTUC), renal masses, and parenchymal pathology. Excretory phase essential for urothelial evaluation.
• 4lab Complete Blood Count with Differential
  Baseline cytopenia assessment and ongoing monitoring of myelosuppression.
• 5lab Comprehensive Metabolic Panel
  Електроліти (Na, K, Cl, HCO3), креатинін + BUN (renal function), глюкоза, кальцій, альбумін, total protein. Базова метаболічна оцінка перед будь-якою терапією + основа TLS risk + dosing adjustments.
• 6lab Liver Function Tests
  Assess hepatic function — baseline + during BR cycles + DAA therapy + HBV reactivation monitoring.
• 7lab Renal function panel with eGFR (creatinine, BUN, electrolytes)
  Baseline renal function before iodinated contrast, nephrotoxic systemic therapy, partial vs radical nephrectomy planning, and HRR / cisplatin eligibility.

MDT brief