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Reported CD30 expression in T-cell lymphoma; a targeting signal requiring confirmed patho...

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IDRF-TCELL-CD30-POSITIVE
TipoSinal de alerta
Estadopending_clinical_signoff
DoençasDIS-AITL DIS-ALCL DIS-PTCL-NOS
FontesSRC-ADCETRIS-US-LABEL SRC-ECHELON-2-FIVE-YEAR-2022 SRC-ESMO-EHA-PTCL-2025

Origem da bandeira vermelha

DefiniçãoReported CD30 expression in T-cell lymphoma; a targeting signal requiring confirmed pathology and histology-specific treatment review.
Direcção clínicaintensificar
Categoriahigh-risk-biology
Algoritmo de deslocamentosALGO-PTCL-1L, ALGO-AITL-1L, ALGO-ALCL-1L, ALGO-MF-SEZARY-1L

Lógica de Desencadeamento

{
  "any_of": [
    {
      "finding": "BIO-CD30-IHC",
      "value": "positive"
    },
    {
      "finding": "cd30_positive",
      "value": true
    }
  ],
  "type": "biomarker"
}

Notas

CD30 expression alone does not establish treatment eligibility or universal BV-CHP preference. ECHELON-2 compared with CHOP, not CHOEP. Pooled benefit must not be attributed to each histology. Regulatory authorization and access require separate regional verification; no Ukrainian reimbursement assertion is made here.

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Indicação

Sinal de alerta