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Infecção crônica por hepatite B (HBsAg+ ≥6 meses OR ADN-HBV detectável ≥ 6 meses) num...

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IDRF-CHRONIC-HBV-MALIGNANCY-PREVENTION
TipoSinal de alerta
Estadoreviewed 2026-05-18 | pending_clinical_signoff
DoençasDIS-HCC
FontesSRC-AASLD-HBV-2024 SRC-AASLD-HCC-2023 SRC-EASL-HBV-2025

Origem da bandeira vermelha

DefiniçãoChronic Hepatitis B infection (HBsAg+ ≥6 months OR HBV-DNA detectable ≥6 months) in an individual without a current HCC or HBV-associated lymphoma diagnosis. IARC Group 1 carcinogen (HBV) — established etiological driver of HCC (lifetime risk 15-25% in untreated chronic HBV per WHO; 5-10x reduction with antiviral suppression) and a contributor to B-cell NHL (HCC the dominant cancer outcome). Long-term nucleos(t)ide analog suppression (entecavir / tenofovir TDF or TAF) reduces HCC incidence. Prevention-persona RedFlag (§20 ratification 2026-05-18).
Direcção clínicainvestigar
CategoriaOutros

Lógica de Desencadeamento

{
  "any_of": [
    {
      "finding": "hbsag",
      "value": "positive"
    },
    {
      "finding": "hbv_dna",
      "value": "detectable"
    },
    {
      "finding": "hbv_chronic_status",
      "value": "positive"
    }
  ],
  "type": "lab_value"
}

Notas

Prevention-persona RedFlag for HBV-associated cancer prevention. Fires on HBsAg+ OR detectable HBV-DNA in patient without HCC. Engine routes to PreventionPlan recommending nucleos(t)ide analog suppression (per IND-CHRONIC-HBV-PREVENTION-ANTIVIRAL) + AFP+US HCC surveillance q6mo per AASLD protocol. STUB pending Co-Lead review. Cancer scope: anchor target DIS-HCC. HBV-associated DLBCL/NHL is also documented in literature but with weaker effect-size data than the HCV-NHL link; covered via the broader NHL prevention surveillance bullet in the antiviral indication rationale. Distinct from RF-UNIVERSAL-HBV-REACTIVATION-RISK (existing) which is the treatment-time RF for HBV reactivation during anti-CD20 / chemo.

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Indicação

Sinal de alerta