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Linfoma de grande célula B do mediastino primário (fímico)

Visão determinística da entidade fonte YAML. A autoridade clínica permanece com os IDs de fonte citados e estado de assinatura do revisor.

IDDIS-PMBCL
TipoDoença
Alegais
LBCL mediastinalPMBCLPMLBCLLinfoma B-Cell principalПервинна медіастинальна (тимічна) B-великоклітинна лімфома
Estadoreviewed 2026-04-25 | pending_clinical_signoff
DoençasNenhuma declaração
FontesSRC-NCCN-BCELL-2025

Informational support. All recommendations must be verified by a qualified oncologist. Engineering checks are not clinical validation or treatment approval.

Fonte YAML

icd_o_3_morphology9679/3
icd_10C85.2
who_classificationAggressive B-cell lymphomas — Primary mediastinal (thymic) large B-cell lymphoma per WHO 5th ed.

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Notas

STUB — pending Clinical Co-Lead approval per CHARTER §6.1. CT chest з biopsy of mediastinal mass — initial workup. Avoid steroids перед biopsy if possible. CNS prophylaxis not routine. Differential — anterior/superior mediastinal mass: sarcoidosis (D86.0–D86.2) can present identically to PMBCL on CT (bulky mediastinal mass, bilateral hilar nodes, pleural/pericardial effusions). PET/CT uptake indistinguishable. Biopsy essential; sarcoid granulomata (non-caseating, CD15−/CD30−, no malignant large B-cells) exclude PMBCL. ACE, serum calcium, BAL cell differential help pre-biopsy. Do not start R-CHOP / DA-EPOCH-R on imaging alone.

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