Onco Wiki / Biomarcador

ARN-VHC quantitativo — monitorização da carga viral durante a terapêutica antiviral de ação directa (DAA)

Visão determinística da entidade fonte YAML. A autoridade clínica permanece com os IDs de fonte citados e estado de assinatura do revisor.

IDBIO-HCV-RNA-QUANTITATIVE-MONITORING
TipoBiomarcador
Alegais
PCR do VHC quantitativoMonitorização quantitativa do ARN do VHCMonitorização da carga viral do VHCHCV РНК кількісна — моніторинг вірусного навантаження під час DAA-терапіїAvaliação da RVS12
Estadoreviewed 2026-05-18 | pending_clinical_signoff
DoençasDIS-HCV-MZL
FontesSRC-AASLD-IDSA-HCV-2023 SRC-EASL-HCV-2023

Fatos de biomarcadores

Tipo de biomarcadorviral_load
Medição
MétodoReal-time quantitative PCR (HCV RNA, IU/mL); high-sensitivity assay (LOD ≤15 IU/mL) required for SVR12
UnidadesIU/mL
Gama típica
  • 0
  • 100000000
Biomarcadores relacionadosBIO-HCV-RNA BIO-HCV-STATUS

Notas

Quantitative HCV RNA used to TRACK response over time during 8-12 week course of direct-acting antiviral (DAA) regimens (glecaprevir/ pibrentasvir, sofosbuvir/velpatasvir, sofosbuvir/velpatasvir/voxilaprevir, ledipasvir/sofosbuvir). Distinct from BIO-HCV-RNA which captures the single-timepoint quantitative result; this entry captures the serial-monitoring concept for HCC prevention pathway. AASLD-IDSA / EASL minimum testing protocol: baseline HCV RNA + genotype + cirrhosis staging; on-treatment HCV RNA at week 4 (optional, evaluates adherence/response — undetectable at week 4 = rapid virologic response, RVR; not a stopping rule for modern DAAs); end-of-treatment HCV RNA at completion (week 8 or 12); SVR12 — undetectable HCV RNA 12 weeks after treatment completion = virologic cure (>95% achievable with current DAAs, durable in >99%). SVR12 = primary efficacy endpoint for HCV cure; SVR24 essentially equivalent. Post-SVR HCC surveillance remains REQUIRED in cirrhotic patients (cumulative HCC risk reduced but not eliminated by cure; AASLD recommends ongoing q6-month US ± AFP for cirrhotics regardless of SVR status). Quantitative monitoring also informs reinfection detection (any HCV R...

Usado por

Relevância terapêutica