BMI ≥30 kg/m² (WHO obesity Class I or higher). IARC Working Group on Obesity (Lauby-Secre...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-UNIVERSAL-ELEVATED-BMI-CANCER-CLUSTER`
Type	Red flag
Status	reviewed 2026-05-18 \| pending_clinical_signoff
Diseases	None declared
Sources	`SRC-USPSTF-BREAST-2024` `SRC-USPSTF-CRC-2021` `SRC-WCRF-AICR-CUP-2018`

Red Flag Origin

Definition	BMI ≥30 kg/m² (WHO obesity Class I or higher). IARC Working Group on Obesity (Lauby-Secretan 2016, NEJM) catalogued sufficient evidence for a causal association between excess body fatness and ≥13 cancer types: oesophagus (adenocarcinoma), gastric cardia, colon and rectum, liver, gallbladder, pancreas, postmenopausal breast, corpus uteri, ovary, kidney (renal cell carcinoma), meningioma, thyroid, multiple myeloma. WCRF / AICR Continuous Update Project (2018) corroborates with additional probable evidence for advanced prostate, oral cavity / pharynx / larynx, and provides dose-response curves (HR per 5 kg/m² increase typically 1.1-1.5 across the cluster). Universal RedFlag (relevant_diseases ["*"]) — routes to a structured weight-loss program + cancer-cluster screening cadence modification (priority CRC + breast + endometrial + HCC where USPSTF / NCCN screening is age-and-modality define...
Clinical direction	investigate
Category	other

Trigger Logic

{
  "any_of": [
    {
      "comparator": ">=",
      "finding": "bmi_kg_m2",
      "threshold": 30
    }
  ],
  "type": "lab_value"
}

Notes

Pre-triage universal RedFlag — obesity (BMI≥30) per IARC 13-cancer cluster + WCRF/AICR CUP. Authoring intent: route to structured weight-loss program + cancer-cluster screening modification (CRC priority — adenoma surveillance interval and starting-age individualization; breast supplemental imaging on density; endometrial symptom-prompted TVUS; HCC US+AFP q6mo if NAFLD/MASH-cirrhosis component). With relevant_diseases=["*"], the engine does NOT attach Indication tracks via the prevention path (engine excludes "*" at plan.py:297) — universal Indications anchored to DIS-CRC are documentation / sidecar candidates pending future engine extension. STUB pending two-Clinical-Co-Lead signoff per CHARTER §6.1 dev-mode.

Used By

Indications

IND-UNIVERSAL-ELEVATED-BMI-PREVENTION-COUNSELING-ONLY - IND-UNIVERSAL-ELEVATED-BMI-PREVENTION-COUNSELING-ONLY
IND-UNIVERSAL-ELEVATED-BMI-PREVENTION-WEIGHT-LOSS-SCREENING - IND-UNIVERSAL-ELEVATED-BMI-PREVENTION-WEIGHT-LOSS-SCREENING