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Long-standing endometriosis (especially endometrioma + deep infiltrating forms, duration...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

IDRF-REPRODUCTIVE-ENDOMETRIOSIS-OVARIAN-PREVENTION
TypeRed flag
Statusreviewed 2026-05-19 | pending_clinical_signoff
DiseasesDIS-OVARIAN
SourcesSRC-ESMO-OVARIAN-2024 SRC-NCCN-OVARIAN-2025

Red Flag Origin

DefinitionLong-standing endometriosis (especially endometrioma + deep infiltrating forms, duration ≥5 years) is an established risk factor for ovarian cancer of clear-cell and endometrioid histologic subtypes (RR ~1.3-1.9 overall; up to ~3-4 for clear-cell + endometrioid subtypes specifically; meta-analyses Pearce 2012, Kvaskoff 2021). Mechanism: chronic pelvic inflammation, iron-mediated oxidative stress within endometriomata, somatic mutations in ARID1A/PIK3CA arising in atypical endometriosis. Absolute lifetime ovarian cancer risk modestly elevated (~1.8% vs general population ~1.3%) — counseling balances modest risk increase against avoidance of unnecessary BSO in reproductive-age women. Prevention-persona RedFlag (§20 v0.3 reproductive expansion).
Clinical directioninvestigate
Categoryother

Trigger Logic

{
  "any_of": [
    {
      "finding": "endometriosis_confirmed_duration_ge_5y",
      "value": true
    },
    {
      "finding": "endometrioma_imaging_confirmed",
      "value": true
    },
    {
      "finding": "deep_infiltrating_endometriosis_diagnosed",
      "value": true
    }
  ],
  "type": "lab_value"
}

Notes

Prevention-persona RedFlag for endometriosis-associated ovarian cancer risk. NO routine population-screening tool exists (CA-125 + TVUS not recommended for general or endometriosis screening per NCCN/USPSTF). Counseling: symptom awareness; consider risk-reducing salpingectomy at completed childbearing or at hysterectomy for benign indications; BSO reserved for those with additional risk factors. STUB pending two-Co- Lead signoff per CHARTER §6.1 dev-mode.

Used By

Indications