Reproductive-history risk factors for hormone-driven cancers (breast + endometrial + ovar...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-REPRODUCTIVE-BREAST-ENDOMETRIAL-PREVENTION`
Type	Red flag
Status	reviewed 2026-05-18 \| pending_clinical_signoff
Diseases	`DIS-BREAST` `DIS-ENDOMETRIAL` `DIS-OVARIAN`
Sources	`SRC-ESGO-ENDOMETRIAL-2025` `SRC-NCCN-BCELL-2025`

Red Flag Origin

Definition	Reproductive-history risk factors for hormone-driven cancers (breast + endometrial + ovarian primarily): nulliparity, late first pregnancy (≥30 years), early menarche (<12 years), late menopause (≥55 years), combined hormone replacement therapy (HRT) ≥5 years, OR persistent anovulation (PCOS, perimenopause). Each independently confers modest RR ~1.2-1.5 for hormone-receptor-positive breast cancer + endometrial cancer. Cumulative effect non-trivial. Prevention-persona RedFlag (§20 v0.3 reproductive).
Clinical direction	investigate
Category	other

Trigger Logic

{
  "any_of": [
    {
      "finding": "nulliparous_age_ge_30",
      "value": true
    },
    {
      "finding": "early_menarche_age_lt_12",
      "value": true
    },
    {
      "finding": "late_menopause_age_ge_55",
      "value": true
    },
    {
      "finding": "combined_hrt_use_ge_5y",
      "value": true
    },
    {
      "finding": "persistent_anovulation_or_pcos",
      "value": true
    }
  ],
  "type": "lab_value"
}

Notes

Prevention-persona RedFlag for reproductive-history risk factors. Effect sizes are modest individually but cumulative significant. STUB pending two-Co-Lead signoff.

Used By

Indications

IND-REPRODUCTIVE-BREAST-ENDOMETRIAL-PREVENTION-COUNSELING - IND-REPRODUCTIVE-BREAST-ENDOMETRIAL-PREVENTION-COUNSELING
IND-REPRODUCTIVE-BREAST-ENDOMETRIAL-PREVENTION-OBSERVATION - IND-REPRODUCTIVE-BREAST-ENDOMETRIAL-PREVENTION-OBSERVATION