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PV or ET patient elderly or frail (age ≥80, ECOG ≥3, multiple comorbidities, life expecta...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

IDRF-PV-ET-FRAILTY-AGE
TypeRed flag
Statusreviewed 2026-04-25 | pending_clinical_signoff
DiseasesDIS-ET DIS-PV
SourcesSRC-ESMO-MPN-2015 SRC-NCCN-MPN-2025

Red Flag Origin

DefinitionPV or ET patient elderly or frail (age ≥80, ECOG ≥3, multiple comorbidities, life expectancy <5 years) — gentler cytoreduction (lower HU dose), expanded transfusion + monitoring strategy
Clinical directionde-escalate
Categoryfrailty-age

Trigger Logic

{
  "any_of": [
    {
      "comparator": ">=",
      "finding": "age_years",
      "threshold": 80
    },
    {
      "finding": "mpn_frail_unfit",
      "value": true
    }
  ],
  "type": "composite"
}

Notes

Direction "investigate"-equivalent — surfaces dose-attenuation annotation; does not switch indication. Older patients tolerate HU well long-term but the leukemogenic-conversion concern weighs less; choice often defaults to HU 1L regardless of age. STUB — requires clinical co-lead signoff.

Used By

Algorithms

Indications