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Spinal cord compression OR rapid PSA doubling time (<3 months) OR new visceral metastases...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

IDRF-PROSTATE-TRANSFORMATION-PROGRESSION
TypeRed flag
Statuspending_clinical_signoff
DiseasesDIS-PROSTATE
SourcesSRC-ESMO-PROSTATE-2024 SRC-NCCN-PROSTATE-2025

Red Flag Origin

DefinitionSpinal cord compression OR rapid PSA doubling time (<3 months) OR new visceral metastases — emergency or aggressive-progression flag requiring urgent intervention or treatment intensification.
Clinical directionhold
Categorytransformation-progression

Trigger Logic

{
  "any_of": [
    {
      "finding": "spinal_cord_compression",
      "value": true
    },
    {
      "comparator": "<",
      "finding": "psa_doubling_time_months",
      "threshold": 3
    },
    {
      "finding": "new_visceral_metastases",
      "value": true
    }
  ],
  "type": "composite_clinical"
}

Notes

Spinal cord compression: emergent neurosurgical / RT consult AND immediate testosterone suppression (degarelix preferred for speed vs LHRH agonists). PSA doubling time <3 months in nmCRPC: criterion for ARPI initiation per NCCN. Visceral mets in mCRPC: docetaxel or cabazitaxel preferred over additional ARPI (cross-resistance). Direction `hold` reflects priority — emergent care precedes scheduled systemic therapy decisions.

Used By

Indications