Documented occupational aromatic-amine exposure — benzidine, 2-naphthylamine, 4-aminobiph...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-OCC-AROMATIC-AMINES-MALIGNANCY-PREVENTION`
Type	Red flag
Status	reviewed 2026-05-18 \| pending_clinical_signoff
Diseases	`DIS-UROTHELIAL`
Sources	`SRC-NCCN-BCELL-2025`

Red Flag Origin

Definition	Documented occupational aromatic-amine exposure — benzidine, 2-naphthylamine, 4-aminobiphenyl — primarily in historical pre-regulation dye, rubber, leather, pigment, and chemical-manufacturing industries (mostly pre-1980s in regulated countries; ongoing in unregulated jurisdictions). IARC Group 1 carcinogen for bladder cancer. Engine routes to PreventionPlan recommending annual urinalysis + cytology + low-threshold cystoscopy for hematuria + smoking cessation.
Clinical direction	investigate
Category	other

Trigger Logic

{
  "any_of": [
    {
      "finding": "occupational_aromatic_amine_exposure_documented",
      "value": true
    },
    {
      "finding": "occupational_dye_rubber_leather_industry_pre_regulation",
      "value": true
    }
  ],
  "type": "lab_value"
}

Notes

Prevention-persona RedFlag for aromatic-amines → urothelial bladder cancer prevention. Fires on documented occupational exposure. DIS-UROTHELIAL anchor preferred but using DIS-HCC as fallback if not in KB on this branch. STUB pending two-Clinical-Co-Lead signoff per CHARTER §6.1 dev-mode.

Used By

Indications

IND-OCC-AROMATIC-AMINES-PREVENTION-OBSERVATION - IND-OCC-AROMATIC-AMINES-PREVENTION-OBSERVATION
IND-OCC-AROMATIC-AMINES-PREVENTION-SURVEILLANCE - IND-OCC-AROMATIC-AMINES-PREVENTION-SURVEILLANCE