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NSCLC with superior vena cava syndrome: facial/upper-extremity edema, distended neck/ches...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

IDRF-NSCLC-SVC-SYNDROME
TypeRed flag
Statusreviewed 2026-04-27 | pending_clinical_signoff
DiseasesDIS-NSCLC
SourcesSRC-ESMO-NSCLC-METASTATIC-2024 SRC-NCCN-NSCLC-2025

Red Flag Origin

DefinitionNSCLC with superior vena cava syndrome: facial/upper-extremity edema, distended neck/chest veins, dyspnea, plethora, headache — most often right-upper-lobe / bulky mediastinal NSCLC
Clinical directionhold
Categoryorgan-dysfunction
Shifts algorithmALGO-NSCLC-METASTATIC-1L

Trigger Logic

{
  "any_of": [
    {
      "finding": "svc_syndrome_present",
      "value": true
    },
    {
      "finding": "facial_upper_extremity_edema",
      "value": true
    },
    {
      "finding": "distended_neck_veins",
      "value": true
    }
  ],
  "type": "composite"
}

Notes

SVC syndrome occurs in ~5-10% of NSCLC at presentation. Per NCCN-NSCLC: emergency endovascular SVC stenting OR urgent palliative RT (30 Gy/10 fx) is first-line stabilization; chemoradiation begun in parallel for limited-stage; systemic therapy started thereafter for metastatic. Direction HOLD on definitive systemic therapy until SVC obstruction relieved (stent or RT). Priority 12. STUB — requires clinical co-lead signoff.

Used By

Indications