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NSCLC with symptomatic malignant pleural / pericardial effusion: dyspnea at rest, hypoxia...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

IDRF-NSCLC-MALIGNANT-EFFUSION
TypeRed flag
Statusreviewed 2026-04-27 | pending_clinical_signoff
DiseasesDIS-NSCLC
SourcesSRC-ESMO-NSCLC-METASTATIC-2024 SRC-NCCN-NSCLC-2025

Red Flag Origin

DefinitionNSCLC with symptomatic malignant pleural / pericardial effusion: dyspnea at rest, hypoxia, hemodynamic compromise (effusion-driven hypotension or tamponade physiology)
Clinical directionhold
Categoryorgan-dysfunction
Shifts algorithmALGO-NSCLC-METASTATIC-1L

Trigger Logic

{
  "any_of": [
    {
      "finding": "malignant_pleural_effusion_symptomatic",
      "value": true
    },
    {
      "finding": "pericardial_effusion_tamponade",
      "value": true
    },
    {
      "finding": "hypoxia_at_rest",
      "value": true
    }
  ],
  "type": "composite"
}

Notes

Per NCCN-NSCLC: thoracentesis ± indwelling pleural catheter ± talc pleurodesis for symptomatic relief before / parallel to systemic therapy. Pericardial effusion: window or pericardiocentesis depending on tamponade status. Note: malignant pleural effusion classifies disease as M1a (per AJCC 8th ed.) → systemic therapy is the pathway, not curative-intent treatment. Direction HOLD until symptomatic relief achieved. Priority 30. STUB — requires clinical co-lead signoff.

Used By

Indications