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Visceral organ involvement (pulmonary, gastrointestinal, or other visceral site) OR exten...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

IDRF-KAPOSI-VISCERAL-EXTENSIVE-DISEASE
TypeRed flag
Statusreviewed 2026-07-11 | pending_clinical_signoff
DiseasesDIS-KAPOSI
SourcesSRC-NCCN-SKIN-2025 SRC-NIH-AIDS-2024

Red Flag Origin

DefinitionVisceral organ involvement (pulmonary, gastrointestinal, or other visceral site) OR extensive/rapidly progressive mucocutaneous disease (widespread cutaneous lesions, tumor-associated lymphedema, or ulceration) in Kaposi sarcoma of any epidemiologic form (AIDS- associated, iatrogenic, classic, or endemic). Symptomatic/extensive disease of this kind is not expected to be adequately controlled by immune restoration (ART / immunosuppression rebalance) or local therapy alone and drives escalation to systemic chemotherapy.
Clinical directionintensify
Categoryrisk-score
Shifts algorithmALGO-KAPOSI-1L

Trigger Logic

{
  "any_of": [
    {
      "finding": "kaposi_visceral_involvement",
      "value": true
    },
    {
      "finding": "kaposi_pulmonary_involvement",
      "value": true
    },
    {
      "finding": "kaposi_gi_involvement",
      "value": true
    },
    {
      "finding": "kaposi_extensive_cutaneous_disease",
      "value": true
    }
  ],
  "type": "symptom_composite"
}

Notes

New disease-extent gate authored for the DIS-KAPOSI treatment pathway (v0.3 continuation -- closes the "missing TREATMENT-intent Indications" gap). Distinct from the pre-existing PREVENTION-persona RF-CHRONIC-HHV8-MALIGNANCY-PREVENTION, which fires on HHV-8 seropositivity in an immunocompromised host BEFORE any Kaposi diagnosis. New finding keys (kaposi_visceral_involvement / kaposi_pulmonary_involvement / kaposi_gi_involvement / kaposi_extensive_cutaneous_disease) -- no equivalent finding existed elsewhere in the KB. INDEPENDENT REVIEW CORRECTION (2026-07-11): an earlier draft of this trigger also fired on a "kaposi_actg_tumor_stage: T1" finding, invoking the ACTG/Krown Kaposi-sarcoma tumor-extent staging system. That specific formal sub-staging criterion is not stated in the authoring narrative and is not documented by either cited source in this KB, so per CHARTER §8.3 (do not invent a clinical criterion beyond the narrative or a verifiable source) it was removed. The remaining trigger clauses (visceral / pulmonary / GI involvement, extensive cutaneous disease) map directly to language in the authoring narrative ("disease extent (limited-cutaneous vs visceral/advanced)"; "syste...

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