History of therapeutic radiation exposure ≥5 years ago to a body region — most commonly m...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-IATROGENIC-PRIOR-RADIATION-PREVENTION`
Type	Red flag
Status	reviewed 2026-05-18 \| pending_clinical_signoff
Diseases	`DIS-AML` `DIS-BREAST` `DIS-LEIOMYOSARCOMA` `DIS-NSCLC` `DIS-OSTEOSARCOMA`
Sources	`SRC-NCCN-BCELL-2025` `SRC-NCCN-CERVICAL-2025`

Red Flag Origin

Definition	History of therapeutic radiation exposure ≥5 years ago to a body region — most commonly mantle / chest radiotherapy for Hodgkin lymphoma in adolescence/young adulthood; breast/thorax RT for childhood cancers; pelvic RT for testicular / cervical / rectal cancer. Increased risk of radiation-induced second primary malignancies in irradiated field: breast cancer (post-mantle RT in women), sarcoma, thyroid cancer, lung cancer, esophageal cancer, secondary leukemia. Risk peaks 10-30 years post-RT. Prevention-persona RedFlag (§20 v0.3 iatrogenic).
Clinical direction	investigate
Category	other

Trigger Logic

{
  "any_of": [
    {
      "finding": "history_therapeutic_radiation_ge_5y_ago",
      "value": true
    },
    {
      "finding": "history_mantle_field_radiotherapy",
      "value": true
    },
    {
      "finding": "history_childhood_cancer_radiotherapy",
      "value": true
    }
  ],
  "type": "lab_value"
}

Notes

Prevention-persona RedFlag for prior therapeutic radiation. Childhood Cancer Survivor Study + LATE consortium document increased second primary malignancy risk decades post-RT. STUB pending two-Co-Lead signoff.

Used By

Indications

IND-IATROGENIC-PRIOR-RADIATION-PREVENTION-OBSERVATION - IND-IATROGENIC-PRIOR-RADIATION-PREVENTION-OBSERVATION
IND-IATROGENIC-PRIOR-RADIATION-PREVENTION-SURVEILLANCE - IND-IATROGENIC-PRIOR-RADIATION-PREVENTION-SURVEILLANCE