Hepatic dysfunction (Child-Pugh B/C, bilirubin >3xULN) at HSTCL diagnosis — disease itsel...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-HSTCL-ORGAN-DYSFUNCTION`
Type	Red flag
Status	reviewed 2026-04-25 \| pending_clinical_signoff
Diseases	`DIS-HSTCL`
Sources	`SRC-ESMO-PTCL-2024` `SRC-NCCN-BCELL-2025`

Red Flag Origin

Definition	Hepatic dysfunction (Child-Pugh B/C, bilirubin >3xULN) at HSTCL diagnosis — disease itself causes hepatosplenomegaly + cytopenias; ifosfamide + carboplatin + etoposide (ICE) induction toxicity exacerbated.
Clinical direction	investigate
Category	organ-dysfunction

Trigger Logic

{
  "any_of": [
    {
      "finding": "child_pugh_class",
      "value": "B"
    },
    {
      "finding": "child_pugh_class",
      "value": "C"
    },
    {
      "comparator": ">",
      "finding": "bilirubin_x_uln",
      "threshold": 3
    }
  ],
  "type": "composite_clinical"
}

Notes

HSTCL almost always presents with hepatosplenomegaly + cytopenias; baseline LFT abnormalities common. Hepatology + hematology co-management critical; supportive care intensified.

Used By

No reverse references found in the YAML corpus.