Family pedigree suggestive of HPRC (Hereditary Papillary Renal Cancer) — MET-driven type...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-HPRC-FAMILY-HISTORY-SUSPICION`
Type	Red flag
Status	reviewed 2026-05-18 \| pending_clinical_signoff
Diseases	`DIS-RCC`
Sources	`SRC-NCCN-BCELL-2025`

Red Flag Origin

Definition	Family pedigree suggestive of HPRC (Hereditary Papillary Renal Cancer) — MET-driven type 1 papillary RCC inheritance, autosomal dominant — with bilateral/multifocal papillary type 1 RCC OR ≥2 first/second- degree relatives with papillary type 1 RCC OR family confirmed MET pathogenic variant. Prevention-persona RedFlag (§20 v0.2-B).
Clinical direction	investigate
Category	other

Trigger Logic

{
  "any_of": [
    {
      "finding": "family_met_known_pathogenic_variant",
      "value": true
    },
    {
      "finding": "family_papillary_type1_rcc_first_or_second_degree",
      "value": true
    },
    {
      "finding": "family_bilateral_multifocal_papillary_rcc",
      "value": true
    }
  ],
  "type": "lab_value"
}

Notes

Prevention-persona RedFlag for HPRC. STUB pending two-Co-Lead signoff.

Used By

Indications

IND-HPRC-SUSPICION-PREVENTION-ENHANCED-SURVEILLANCE - IND-HPRC-SUSPICION-PREVENTION-ENHANCED-SURVEILLANCE
IND-HPRC-SUSPICION-PREVENTION-GENETIC-COUNSELING - IND-HPRC-SUSPICION-PREVENTION-GENETIC-COUNSELING

Red flag

RF-HPRC-CONFIRMED-CARRIER - Confirmed germline pathogenic / likely-pathogenic variant in the MET proto-oncogene — Her...