Age ≥75 with ECOG ≥2, ≥2 comorbidities, weight loss >5%, or albumin <3.5 g/dL — concurren...

Name: Age ≥75 with ECOG ≥2, ≥2 comorbidities, weight loss >5%, or albumin <3.5 g/dL — concurren... - OpenOnco
License: https://creativecommons.org/licenses/by/4.0/

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-HNSCC-FRAILTY-AGE`
Type	Red flag
Status	reviewed 2026-04-26 \| pending_clinical_signoff
Diseases	`DIS-HNSCC`
Sources	`SRC-NCCN-NSCLC-2025`

Red Flag Origin

Definition	Age ≥75 with ECOG ≥2, ≥2 comorbidities, weight loss >5%, or albumin <3.5 g/dL — concurrent high-dose cisplatin chemoradiation poorly tolerated; consider weekly cisplatin, carboplatin, cetuximab + RT, or definitive RT alone with prophylactic gastrostomy.
Clinical direction	de-escalate
Category	frailty-age

Trigger Logic

{
  "any_of": [
    {
      "all_of": [
        {
          "comparator": ">=",
          "finding": "age_years",
          "threshold": 75
        },
        {
          "any_of": [
            {
              "comparator": ">=",
              "finding": "ecog_status",
              "threshold": 2
            },
            {
              "comparator": ">=",
              "finding": "comorbidity_count",
              "threshold": 2
            }
          ]
        }
      ]
    },
    {
      "comparator": "<",
      "finding": "albumin_g_dl",
      "threshold": 3.5
    },
    {
      "comparator": ">",
      "finding": "weight_loss_percent",
      "threshold": 5
    }
  ],
  "type": "composite_clinical"
}

Notes

Historical notes contain a retired source reference. Consult the original YAML for audit history.

Used By

No reverse references found in the YAML corpus.