Age ≥75 with ECOG ≥2 or ≥2 comorbidities — high-dose imatinib 800 mg (KIT exon 9) and TKI...

Name: Age ≥75 with ECOG ≥2 or ≥2 comorbidities — high-dose imatinib 800 mg (KIT exon 9) and TKI... - OpenOnco
License: https://creativecommons.org/licenses/by/4.0/

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-GIST-FRAILTY-AGE`
Type	Red flag
Status	reviewed 2026-04-26 \| pending_clinical_signoff
Diseases	`DIS-GIST`
Sources	`SRC-NCCN-MELANOMA-2025`

Red Flag Origin

Definition	Age ≥75 with ECOG ≥2 or ≥2 comorbidities — high-dose imatinib 800 mg (KIT exon 9) and TKI sequencing into sunitinib / regorafenib poorly tolerated; consider imatinib 400 mg, dose reductions, and earlier supportive-care emphasis.
Clinical direction	de-escalate
Category	frailty-age

Trigger Logic

{
  "all_of": [
    {
      "comparator": ">=",
      "finding": "age_years",
      "threshold": 75
    },
    {
      "any_of": [
        {
          "comparator": ">=",
          "finding": "ecog_status",
          "threshold": 2
        },
        {
          "comparator": ">=",
          "finding": "comorbidity_count",
          "threshold": 2
        }
      ]
    }
  ],
  "type": "composite_clinical"
}

Notes

Historical notes contain a retired source reference. Consult the original YAML for audit history.

Used By

No reverse references found in the YAML corpus.