Geriatric vulnerability flag: age ≥75 AND G8 screening score ≤14 (out of 17 max). Trigger...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-FRAILTY-AGE-G8-LOW`
Type	Red flag
Status	reviewed 2026-04-27 \| pending_clinical_signoff
Diseases	None declared
Sources	`SRC-ESMO-DLBCL-2024` `SRC-NCCN-BCELL-2025`

Red Flag Origin

Definition	Geriatric vulnerability flag: age ≥75 AND G8 screening score ≤14 (out of 17 max). Triggers comprehensive geriatric assessment (CGA) and de-escalation toward attenuated regimens. G8 ≤14 has 85% sensitivity and 65% specificity for impaired CGA in oncology populations (Bellera et al. 2012, Decoster et al. 2015).
Clinical direction	de-escalate
Category	fitness-eligibility

Trigger Logic

{
  "all_of": [
    {
      "comparator": ">=",
      "finding": "age",
      "threshold": 75
    },
    {
      "comparator": "<=",
      "finding": "g8_score",
      "threshold": 14
    }
  ],
  "type": "composite_score"
}

Notes

G8 is the SIOG-recommended screening tool for older oncology patients. Score ≤14 mandates full CGA (Charlson, IADL, MNA, MMSE, GDS) before regimen selection. SIOG / NCCN Older Adult Oncology guidelines: at G8 ≤14, default to dose-attenuated chemotherapy (R-mini-CHOP for DLBCL >80, attenuated VRD for myeloma in unfit, ABVD over BEACOPP for Hodgkin >60, FCR contraindicated in CLL >65). Distinct from RF-FITNESS- ECOG-POOR — a patient can be ECOG 1 yet G8-vulnerable due to cognitive/social/nutritional fragility.

Used By

Red flag

RF-CAR-T-INELIGIBLE-AGE-COMORBID - Composite age + comorbidity exclusion from CAR-T: age ≥75 with Charlson Comorbidity Index...