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Intermediate performance status (ECOG 2): patient ambulatory and capable of self-care but...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

IDRF-FITNESS-ECOG-INTERMEDIATE
TypeRed flag
Statusreviewed 2026-04-27 | pending_clinical_signoff
DiseasesNone declared
SourcesSRC-ESMO-DLBCL-2024 SRC-NCCN-BCELL-2025

Red Flag Origin

DefinitionIntermediate performance status (ECOG 2): patient ambulatory and capable of self-care but unable to carry out work; up and about >50% of waking hours. Generally not a candidate for dose-intensive regimens; modified / dose-attenuated therapy preferred (mini-CHOP, R-mini-CHOP, attenuated BEACOPP, attenuated CODOX-M/IVAC; CAR-T case-by-case).
Clinical directionde-escalate
Categoryfitness-eligibility

Trigger Logic

{
  "all_of": [
    {
      "comparator": "==",
      "finding": "ecog",
      "threshold": 2
    }
  ],
  "type": "composite_score"
}

Notes

ECOG 2 is the borderline zone where most intensified regimens lose benefit and gain toxicity. R-CHOP standard, R-mini-CHOP for elderly ECOG 2, ABVD over BEACOPP for Hodgkin, dose-attenuated DA-EPOCH-R selectable per case. CAR-T trials (ZUMA-1, JULIET) excluded ECOG ≥2; real-world evidence supports ECOG 2 with adequate organ function, but admission protocols vary. Geriatric assessment recommended at ECOG 2 for patients >70 to disambiguate frailty vs disease burden.

Used By

Algorithms