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Frailty profile influencing CLL regimen selection: ECOG ≥3, OR (age ≥75 with G8 ≤14), OR...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

Red Flag Origin

Trigger Logic

{
  "any_of": [
    {
      "comparator": ">=",
      "finding": "ecog",
      "threshold": 3
    },
    {
      "all_of": [
        {
          "comparator": ">=",
          "finding": "age",
          "threshold": 75
        },
        {
          "comparator": "<=",
          "finding": "g8_score",
          "threshold": 14
        }
      ]
    },
    {
      "all_of": [
        {
          "comparator": ">=",
          "finding": "age",
          "threshold": 70
        },
        {
          "comparator": ">=",
          "finding": "charlson_score",
          "threshold": 3
        },
        {
          "comparator": "<",
          "finding": "albumin_g_dl",
          "threshold": 3.5
        }
      ]
    },
    {
      "comparator": ">",
      "finding": "cirs_score",
      "threshold": 6
    }
  ],
  "type": "composite_score"
}

Notes

CIRS (Cumulative Illness Rating Scale) >6 = "unfit" per CLL11 / CLL14 trial criteria — drives choice of obinutuzumab + venetoclax over chemoimmuno. Continuous BTKi (acalabrutinib, zanubrutinib) is also appropriate but requires daily compliance + cardiac monitoring; V+O is fixed-duration 12 months which many elderly prefer (definite end-date, lower long-term toxicity). Avoid ibrutinib first-gen in ≥75 with cardiovascular comorbidity. FCR/BR chemoimmuno absolutely contraindicated — TRM 5-10% in unfit + minimal benefit over targeted therapy.

Used By

No reverse references found in the YAML corpus.