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Chronic pancreatitis — alcoholic etiology (≥10y heavy use), hereditary (PRSS1 or SPINK1 p...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

IDRF-CHRONIC-PANCREATITIS-PDAC-PREVENTION
TypeRed flag
Statusreviewed 2026-05-18 | pending_clinical_signoff
DiseasesDIS-PDAC
SourcesSRC-NCCN-BCELL-2025

Red Flag Origin

DefinitionChronic pancreatitis — alcoholic etiology (≥10y heavy use), hereditary (PRSS1 or SPINK1 pathogenic variant), or new-onset diabetes after age 50 with pancreatic stigmata. Lifetime PDAC risk: ~5% in alcoholic chronic pancreatitis; ~40-50% in hereditary pancreatitis by age 70 (per EUROPAC). Engine routes to PreventionPlan with PDAC surveillance + risk-factor modification.
Clinical directioninvestigate
Categoryother

Trigger Logic

{
  "any_of": [
    {
      "finding": "chronic_pancreatitis_alcohol_associated_duration_ge_10y",
      "value": true
    },
    {
      "finding": "chronic_pancreatitis_hereditary_pancreatitis_prss1_or_spink1",
      "value": true
    },
    {
      "finding": "chronic_pancreatitis_with_diabetes_new_onset_after_50",
      "value": true
    }
  ],
  "type": "lab_value"
}

Notes

Prevention-persona RedFlag for chronic pancreatitis → PDAC. Hereditary pancreatitis carries highest risk (~40-50% lifetime). STUB pending two-Co-Lead signoff.

Used By

Indications