Onco Wiki / Red flag

APL patient with positive HBV / HCV / HIV serology, latent TB, or active uncontrolled inf...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

Red Flag Origin

Trigger Logic

{
  "any_of": [
    {
      "finding": "hbsag",
      "value": "positive"
    },
    {
      "finding": "anti_hbc_total",
      "value": "positive"
    },
    {
      "finding": "hcv_rna",
      "value": "positive"
    },
    {
      "finding": "hiv_status",
      "value": "positive"
    },
    {
      "finding": "active_uncontrolled_infection",
      "value": true
    }
  ],
  "type": "composite"
}

Notes

Direction "hold" — surfaces a pre-consolidation prerequisite. APL induction (ATRA + ATO ± idarubicin) does not delay for serology; consolidation cycles use anthracycline-containing regimens that warrant HBV-active prophylaxis if serologically at risk. STUB — requires clinical co-lead signoff.

Used By

Algorithms

• ALGO-APL-1L - ALGO-APL-1L
• ALGO-APL-2L - ALGO-APL-2L

Indications

• IND-APL-RELAPSED-GEMTUZUMAB - IND-APL-RELAPSED-GEMTUZUMAB
• IND-APL-SALVAGE-ATRA-ATO - IND-APL-SALVAGE-ATRA-ATO