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AML patient with positive HBV / HCV / HIV serology, latent TB, or active uncontrolled inf...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

IDRF-AML-INFECTION-SCREENING
TypeRed flag
Statusreviewed 2026-04-25 | pending_clinical_signoff
DiseasesDIS-AML
SourcesSRC-ELN-AML-2022 SRC-NCCN-AML-2025

Red Flag Origin

DefinitionAML patient with positive HBV / HCV / HIV serology, latent TB, or active uncontrolled infection — needs antiviral prophylaxis (HBV-active prophylaxis with entecavir/tenofovir; HCV expert consult; ART optimization for HIV; TB treatment) before induction
Clinical directionhold
Categoryinfection-screening

Trigger Logic

{
  "any_of": [
    {
      "finding": "hbsag",
      "value": "positive"
    },
    {
      "finding": "anti_hbc_total",
      "value": "positive"
    },
    {
      "finding": "hcv_rna",
      "value": "positive"
    },
    {
      "finding": "hiv_status",
      "value": "positive"
    },
    {
      "finding": "active_uncontrolled_infection",
      "value": true
    },
    {
      "finding": "latent_tb",
      "value": true
    }
  ],
  "type": "composite"
}

Notes

Direction "hold" surfaces a workup-prerequisite annotation. AML induction (anthracycline + cytarabine) and ven+aza both cause profound immunosuppression with high HBV-reactivation risk if HBsAg+ or anti-HBc+ without prophylaxis. HBV testing mandatory pre-induction. STUB — requires clinical co-lead signoff.

Used By

Algorithms

Indications