Colorectal carcinoma (CRC) · None

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

Knowledge-base record for audit. Provisional clinical content: this is not a prescription. An oncologist must verify original sources, applicability and review status. Full rules and constraints are in the YAML.

Source YAML: complete record

Track	standard
Linked regimen	`None`

ID	`IND-LYNCH-CARRIER-SURVEILLANCE`
Type	Indication
Status	reviewed 2026-05-18 \| pending_clinical_signoff
Diseases	`DIS-CRC`
Sources	`SRC-ASCO-ACMG-LYNCH-2014` `SRC-ESMO-CRC-2024` `SRC-NCCN-GENETIC-FAMILIAL-CRC-2025`

Notes

STUB — v0.2-B confirmed-carrier surveillance pathway (Lynch). Two-Clinical-Co-Lead signoff queued. Sibling — IND-LYNCH-CARRIER-INTENSIFIED (aggressive plan_track).

Used By

Actionability

BMA-AXIN2-GERMLINE-CRC-OLIGODONTIA - AXIN2 germline pathogenic variants cause a Lynch-like attenuated polyposis + oligodontia...
BMA-MSH3-GERMLINE-POLYPOSIS-BIALLELIC - MSH3 germline biallelic pathogenic variants cause MSH3-associated polyposis (Adam et al....
BMA-NTHL1-GERMLINE-NAP-BIALLELIC - NTHL1 germline biallelic (homozygous or compound heterozygous) pathogenic variants cause...
BMA-POLD1-GERMLINE-POLYMERASE-PROOFREADING - POLD1 germline pathogenic variants in the exonuclease (proofreading) domain cause PPAP —...
BMA-POLE-GERMLINE-POLYMERASE-PROOFREADING - POLE germline pathogenic variants in the exonuclease (proofreading) domain cause polymera...

Indication

IND-CASCADE-LYNCH-FDR-POSITIVE-TESTING - IND-CASCADE-LYNCH-FDR-POSITIVE-TESTING
IND-LYNCH-CARRIER-INTENSIFIED - IND-LYNCH-CARRIER-INTENSIFIED

Red flag

RF-LYNCH-CONFIRMED-CARRIER - Confirmed germline pathogenic / likely-pathogenic variant in a Lynch syndrome (MMR / EPCA...
RF-LYNCH-FAMILY-HISTORY-SUSPICION - Family pedigree meeting criteria suggestive of hereditary nonpolyposis colorectal cancer...