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Leucovorin (Folinic acid)

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

IDDRUG-LEUCOVORIN
TypeDrug
Aliases
Folinic acidLeucovorinЛейковорин (Фолінова кислота)
Statusreviewed 2026-04-26 | pending_clinical_signoff
DiseasesDIS-CRC DIS-ESOPHAGEAL DIS-GASTRIC DIS-PDAC DIS-PTCL-NOS
SourcesSRC-NCCN-COLON-2025

Drug Facts

ClassReduced folate (5-formyltetrahydrofolate) — biomodulator
MechanismTetrahydrofolate donor that stabilizes the 5-FU/thymidylate-synthase ternary complex, potentiating 5-FU cytotoxicity. NOT a chemotherapy agent itself in this role — it is given alongside 5-FU. Separately, high-dose leucovorin is used as MTX rescue.
Ukraine registeredTrue
NSZU reimbursedTrue
Ukraine last verified2026-04-27

Notes

Most 5-FU regimens require leucovorin for activity modulation; doses are protocol-specific: Mayo Clinic (20 mg/m² IV bolus pre-5FU), Roswell Park (500 mg/m² IV 2-h infusion), de Gramont / FOLFOX / FOLFIRI (200-400 mg/m² IV 2-h infusion Day 1 ± Day 2). Levoleucovorin (l-isomer) is the active enantiomer; half the dose of racemic leucovorin (10 mg/m² Mayo equivalent). In high-dose methotrexate rescue: 15 mg PO/IV q6h starting 24 h post-MTX, continued until MTX level <0.05-0.1 µM (escalate dose if MTX clearance delayed). Critical safety point: leucovorin rescue dose must be matched to MTX level — under-rescue causes fatal MTX toxicity. UA: зареєстрований; НСЗУ-reimbursed for 5-FU modulation in CRC and as MTX rescue. Generic widely available.

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