Doxazosin
Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.
| ID | DRUG-DOXAZOSIN |
|---|---|
| Type | Drug |
| Aliases | Carduraselective alpha-1 blockerДоксазозин |
| Status | reviewed 2026-07-11 | pending_clinical_signoff |
| Diseases | DIS-PHEOCHROMOCYTOMA |
| Sources | SRC-ENDOCRINE-SOCIETY-PPGL-2014 SRC-NCCN-NET-2025 |
Drug Facts
| Class | Selective, competitive alpha-1 adrenergic receptor antagonist |
|---|---|
| Mechanism | Selectively and reversibly blocks post-synaptic alpha-1 adrenergic receptors, reducing catecholamine-mediated peripheral vasoconstriction with less reflex tachycardia than non-selective irreversible agents (phenoxybenzamine) because alpha-2 presynaptic auto-inhibition of norepinephrine release is preserved. Used as an alternative preoperative alpha-blocker in pheochromocytoma / paraganglioma (PPGL) where mandatory preoperative alpha-blockade is required before surgery to prevent intraoperative hypertensive crisis (Endocrine Society 2014 PPGL guideline). |
| Typical dosing | Starting dose typically 1-2 mg PO once daily, titrated upward every few days as tolerated toward blood-pressure normalization and symptom control ahead of PPGL surgery, per Endocrine Society 2014 PPGL guideline (SRC-ENDOCRINE-SOCIETY-PPGL-2014); usual ceiling in general antihypertensive use is 16 mg/day, though the dose actually required for adequate preoperative PPGL blockade is individualized by the treating team. Usual preoperative course runs roughly one to two weeks before surgery. Exact target BP/HR thresholds are NOT fixed numeric values in this stub -- see RF-PHEO-INADEQUATE-ALPHA-BLOCKADE for the hard sequencing gate this drug exists to satisfy. |
| Ukraine registered | True |
| NSZU reimbursed | False |
| Ukraine last verified | 2026-07-11 |
Notes
Selective alpha-1 blockade gives less reflex tachycardia and easier general availability than phenoxybenzamine (DRUG-PHENOXYBENZAMINE), making doxazosin a commonly used practical alternative for mandatory preoperative PPGL alpha-blockade; choice between the two is per local practice/availability, not modelled as a KB-level preference. STUB pending clinical co-lead signoff (CHARTER §6.1, dev-mode-exempted).
Used By
Drug
DRUG-PHENOXYBENZAMINE- Phenoxybenzamine
Regimens
REG-ALPHA-BLOCKADE-PREOP-PHEO- Preoperative alpha-adrenergic blockade (phenoxybenzamine, before pheochromocytoma/paragan...