Cabergoline
Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.
| ID | DRUG-CABERGOLINE |
|---|---|
| Type | Drug |
| Aliases | DostinexКаберголін |
| Status | reviewed 2026-07-11 | pending_clinical_signoff |
| Diseases | DIS-PITUITARY-ADENOMA |
| Sources | SRC-NCCN-CNS-2025 |
Drug Facts
| Class | Ergot-derived dopamine D2-receptor agonist |
|---|---|
| Mechanism | Selective, high-affinity D2-dopamine receptor agonist with a long elimination half-life (~65 hours) permitting once- or twice-weekly oral dosing. Activates D2 receptors on pituitary lactotroph cells, suppressing prolactin synthesis/secretion and inducing lactotroph adenoma shrinkage in the majority of prolactinomas. First-line therapy for prolactinoma; superior prolactin-normalization rate, tumor-shrinkage rate, and tolerability compared with bromocriptine (older, less selective dopamine agonist). |
| Typical dosing | Start 0.25 mg PO twice weekly (or 0.5 mg PO once weekly); titrate by 0.25-0.5 mg/week increments no more often than every 4 weeks according to serum prolactin response, to a typical maintenance dose of 0.5-2 mg/week in divided doses twice weekly (occasionally higher, up to ~4.5 mg/week, in macroprolactinoma resistant to lower doses). Take with food to reduce nausea. Confirm exact titration schedule with treating endocrinology team. |
| Ukraine registered | True |
| NSZU reimbursed | False |
| Ukraine last verified | 2026-07-11 |
Notes
STUB pending clinical co-lead signoff (CHARTER §6.1 — dev-mode-exempted, safe to merge as draft content, not published/verified clinical advice). Cabergoline is first-line therapy for prolactinoma per the Disease narrative (preferred over bromocriptine for prolactin-normalization rate, tumor shrinkage, and tolerability). Bromocriptine itself is not yet authored as a separate Drug entity in this KB — deferred as an open gap (see DIS-PITUITARY-ADENOMA proposal notes) since the narrative names it only as a comparator, not as a distinct recommended pathway.
Used By
Regimens
REG-CABERGOLINE-PROLACTINOMA- Cabergoline for prolactinoma (dopamine agonist, first-line)