Allograft dysfunction (worsening creatinine if kidney, transaminases if liver, troponin i...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-PTLD-ORGAN-DYSFUNCTION`
Type	Red flag
Status	reviewed 2026-04-25 \| pending_clinical_signoff
Diseases	`DIS-PTLD`
Sources	`SRC-ESMO-DLBCL-2024` `SRC-NCCN-BCELL-2025`

Red Flag Origin

Definition	Allograft dysfunction (worsening creatinine if kidney, transaminases if liver, troponin if heart) at PTLD diagnosis — IS-reduction must be balanced against allograft loss; transplant team co-management mandatory.
Clinical direction	investigate
Category	organ-dysfunction

Trigger Logic

{
  "any_of": [
    {
      "finding": "allograft_dysfunction",
      "value": true
    },
    {
      "comparator": ">=",
      "finding": "creatinine_increase_x_baseline",
      "threshold": 1.5
    }
  ],
  "type": "composite_clinical"
}

Notes

PTLD treatment fundamentally requires IS-reduction; balancing allograft survival vs PTLD response is per-patient clinical decision. Flag mandates transplant team involvement.

Used By

No reverse references found in the YAML corpus.