Age >70 + advanced organ dysfunction OR ECOG ≥3 — full-dose R-CHOP poorly tolerated; redu...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-PTLD-FRAILTY-AGE`
Type	Red flag
Status	reviewed 2026-04-25 \| pending_clinical_signoff
Diseases	`DIS-PTLD`
Sources	`SRC-ESMO-DLBCL-2024` `SRC-NCCN-BCELL-2025`

Red Flag Origin

Definition	Age >70 + advanced organ dysfunction OR ECOG ≥3 — full-dose R-CHOP poorly tolerated; reduced-intensity rituximab-only or modified chemo with growth-factor support.
Clinical direction	de-escalate
Category	frailty-age

Trigger Logic

{
  "any_of": [
    {
      "comparator": ">=",
      "finding": "ecog_status",
      "threshold": 3
    },
    {
      "all_of": [
        {
          "comparator": ">",
          "finding": "age_years",
          "threshold": 70
        },
        {
          "comparator": ">=",
          "finding": "comorbidity_count",
          "threshold": 2
        }
      ]
    }
  ],
  "type": "composite_clinical"
}

Notes

Transplant recipients are usually older with multi-organ comorbidity at PTLD diagnosis. Reduced-intensity approach preserves quality of life; alloSCT obviously not relevant here.

Used By

No reverse references found in the YAML corpus.