STK11 (LKB1) germline pathogenic variant
Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.
| ID | BIO-STK11-GERMLINE |
|---|---|
| Type | Biomarker |
| Aliases | STK11 (LKB1) germline патогенний варіантSTK11 germline pathogenic variant |
| Status | reviewed 2026-05-18 | pending_clinical_signoff |
| Diseases | None declared |
| Sources | SRC-ESMO-CRC-2024 |
Biomarker Facts
| Biomarker type | gene_mutation |
|---|---|
| Mutation details | {"functional_impact": "loss_of_function", "gene": "STK11", "gene_hugo_id": "HGNC:11389", "variant_type": "missense_or_truncating"} |
| Related biomarkers | None declared |
Notes
STK11/LKB1 germline — drives Peutz-Jeghers syndrome. Lifetime cancer risk ~80% across GI + breast + gynecologic + testicular Sertoli + pancreas. STUB.
Used By
No reverse references found in the YAML corpus.