Ki-67 IHC in surveillance/precursor contexts
Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.
| ID | BIO-KI67-IHC-PROLIFERATION-INDEX |
|---|---|
| Type | Biomarker |
| Aliases | Ki-67 in Barrett's HGDKi-67 in dysplastic colonKi-67 proliferation index — surveillance applicationKi-67 ІГХ у нагляді/попередніх ураженняхMIB-1 surveillance |
| Status | reviewed 2026-05-18 |
| Diseases | None declared |
| Sources | SRC-NCCN-COLON-2025 SRC-NCCN-ESOPHAGEAL-2025 |
Biomarker Facts
| Biomarker type | protein_expression_ihc |
|---|---|
| Measurement | MethodIHC on FFPE biopsy (MIB-1 / Ki-67); hot-spot count of nuclear-positive epithelial cells Unitspercentage (0-100% positive nuclei) |
| Related biomarkers | BIO-KI67-PROLIFERATION-INDEX |
Notes
STUB. Companion to BIO-KI67-PROLIFERATION-INDEX (which scopes hematologic treatment selection). Surveillance use case: in Barrett's high-grade dysplasia (HGD), expansion of Ki-67 positivity into the superficial epithelium signals progression risk; in IBD-associated colorectal dysplasia, increased Ki-67 with loss of normal basal-restricted pattern supports dysplasia diagnosis. Not algorithm-impacting standalone — adjunct to morphology + p53.
Used By
No reverse references found in the YAML corpus.