HTLV-1 status (anti-HTLV-1 antibody + confirmatory)

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`BIO-HTLV-1`
Type	Biomarker
Aliases	HTLV-1 serologyHTLV-IHuman T-lymphotropic virus type 1 statusanti-HTLV-1Статус HTLV-1 (антитіла + підтвердження)
Status	reviewed 2026-04-26 \| pending_clinical_signoff
Diseases	None declared
Sources	`SRC-NCCN-BCELL-2025`

Biomarker Facts

Biomarker type	viral_serology
Measurement	MethodAnti-HTLV-1 antibody screening (EIA or particle agglutination); reactive → confirmatory Western blot or line immunoassay to distinguish HTLV-1 from HTLV-2 and rule out indeterminate patterns. HTLV-1 proviral load (qPCR on PBMCs) is informative but not standardized — high proviral load (>4% of PBMCs) correlates with ATLL transformation risk in carriers but is NOT a treatment-decision biomarker in active ATLL. Unitscategorical: HTLV-1 seropositive (carrier vs ATLL clinical) \| seronegative
Related biomarkers	`BIO-HIV-STATUS`

Notes

HTLV-1 etiology is the defining feature of Adult T-Cell Leukemia/Lymphoma (ATLL); WHO classification requires HTLV-1 seropositivity + clonal HTLV-1 integration on Southern blot (or qPCR equivalent) for diagnosis. Geographic context matters for Ukraine: HTLV-1 prevalence is low (<0.1% in non-endemic Europe); endemic areas are Japan, Caribbean, parts of Sub-Saharan Africa, South America. ATLL diagnosis in a Ukrainian patient should prompt travel / heritage history; rare but real. Currently consumed by: ALGO-ATLL-1L (etiology rail — HTLV-1+ is necessary for ATLL classification; subtype determined by clinical features per Shimoyama). Quantitative proviral load monitoring flagged as a future Monitoring entity for asymptomatic carriers who are not currently candidates for treatment. reviewer_signoffs: 0 # STUB — pending two Clinical Co-Lead approvals

Used By

Algorithms

ALGO-ATLL-1L - ALGO-ATLL-1L

Indications

IND-ATLL-1L-AGGRESSIVE - IND-ATLL-1L-AGGRESSIVE
IND-ATLL-1L-INDOLENT-AZT-IFN - IND-ATLL-1L-INDOLENT-AZT-IFN

Questionnaires

QUEST-ATLL-1L-STUB - Adult T-Cell Leukemia/Lymphoma — first line