HTLV-1 status (anti-HTLV-1 antibody + confirmatory)
Детермінований перегляд YAML-сутності з джерельної бази. Клінічний авторитет лишається за вказаними source ID та статусом клінічного sign-off.
| ID | BIO-HTLV-1 |
|---|---|
| Тип | Біомаркер |
| Синоніми | HTLV-1 serologyHTLV-IHuman T-lymphotropic virus type 1 statusanti-HTLV-1Статус HTLV-1 (антитіла + підтвердження) |
| Статус | переглянуто 2026-04-26 | очікує клінічного підпису |
| Хвороби | Не вказано |
| Джерела | SRC-NCCN-BCELL-2025 |
Дані про біомаркер
| Тип біомаркера | viral_serology |
|---|---|
| Вимірювання | MethodAnti-HTLV-1 antibody screening (EIA or particle agglutination); reactive → confirmatory Western blot or line immunoassay to distinguish HTLV-1 from HTLV-2 and rule out indeterminate patterns. HTLV-1 proviral load (qPCR on PBMCs) is informative but not standardized — high proviral load (>4% of PBMCs) correlates with ATLL transformation risk in carriers but is NOT a treatment-decision biomarker in active ATLL. Unitscategorical: HTLV-1 seropositive (carrier vs ATLL clinical) | seronegative |
| Пов’язані біомаркери | BIO-HIV-STATUS |
Нотатки
HTLV-1 etiology is the defining feature of Adult T-Cell Leukemia/Lymphoma (ATLL); WHO classification requires HTLV-1 seropositivity + clonal HTLV-1 integration on Southern blot (or qPCR equivalent) for diagnosis. Geographic context matters for Ukraine: HTLV-1 prevalence is low (<0.1% in non-endemic Europe); endemic areas are Japan, Caribbean, parts of Sub-Saharan Africa, South America. ATLL diagnosis in a Ukrainian patient should prompt travel / heritage history; rare but real. Currently consumed by: ALGO-ATLL-1L (etiology rail — HTLV-1+ is necessary for ATLL classification; subtype determined by clinical features per Shimoyama). Quantitative proviral load monitoring flagged as a future Monitoring entity for asymptomatic carriers who are not currently candidates for treatment. reviewer_signoffs: 0 # STUB — pending two Clinical Co-Lead approvals
Де використовується
Algorithms
ALGO-ATLL-1L- ALGO-ATLL-1L
Indications
IND-ATLL-1L-AGGRESSIVE- IND-ATLL-1L-AGGRESSIVEIND-ATLL-1L-INDOLENT-AZT-IFN- IND-ATLL-1L-INDOLENT-AZT-IFN
Questionnaires
QUEST-ATLL-1L-STUB- Adult T-Cell Leukemia/Lymphoma — first line