JAK2 V617F is one of three defining drivers in essential thrombocythemia (~50-60%; CALR ~...
Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.
| ID | BMA-JAK2-V617F-ET |
|---|---|
| Type | Actionability |
| Status | reviewed 2026-04-27 | pending_clinical_signoff | actionability review required |
| Diseases | DIS-ET |
| Sources | SRC-CIVIC SRC-ESMO-MPN-2015 SRC-NCCN-MPN-2025 SRC-PT1-HARRISON-2005 |
Actionability Facts
| Biomarker | BIO-JAK2 |
|---|---|
| Variant | V617F (exon 14 — present in ~50-60% of essential thrombocythemia) |
| Disease | DIS-ET |
| ESCAT tier | IA |
| Recommended combinations | low-dose aspirin (low-risk per SRC-NCCN-MPN-2025), hydroxyurea + aspirin (high-risk 1L per SRC-PT1-HARRISON-2005), interferon-alpha (preferred for younger high-risk per SRC-NCCN-MPN-2025, SRC-ESMO-MPN-2015), anagrelide (HU-resistant/intolerant 2L) |
| Evidence summary | JAK2 V617F is one of three defining drivers in essential thrombocythemia (~50-60%; CALR ~25-30%, MPL ~3-5%, triple-negative ~10-15%) and a WHO 2022 / ICC 2022 major diagnostic criterion (per SRC-NCCN-MPN-2025, SRC-ESMO-MPN-2015). Treatment is risk-stratified by IPSET-thrombosis (age, prior thrombosis, JAK2 V617F positivity, cardiovascular risk factors); high-risk → cytoreduction with hydroxyurea (PT1 trial Harrison 2005 — superior thrombosis-free survival vs anagrelide in HU-naive ET); low-risk → low-dose aspirin alone (or observation in CALR-mutated very-low-risk per SRC-ESMO-MPN-2015). |
Notes
ESCAT IA / OncoKB Level 1 — JAK2 mutation status is required for diagnosis and risk stratification (IPSET-thrombosis upgrades JAK2- positive patients into higher-risk strata per SRC-ESMO-MPN-2015). V617F allele burden does not determine treatment choice. Source-gap: SRC-NCCN-MPN-2025 STUB; awaits full ingestion.
Used By
No reverse references found in the YAML corpus.