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NSCLC with superior vena cava syndrome: facial/upper-extremity edema, distended neck/ches...

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IDRF-NSCLC-SVC-SYNDROME
TypeSignal d’alerte
Étatreviewed 2026-04-27 | pending_clinical_signoff
MaladiesDIS-NSCLC
SourcesSRC-ESMO-NSCLC-METASTATIC-2024 SRC-NCCN-NSCLC-2025

Origine du drapeau rouge

DéfinitionNSCLC with superior vena cava syndrome: facial/upper-extremity edema, distended neck/chest veins, dyspnea, plethora, headache — most often right-upper-lobe / bulky mediastinal NSCLC
Direction cliniqueen attente
Catégoriedysfonction d'organe
Algorithme de décalageALGO-NSCLC-METASTATIC-1L

Logique de déclenchement

{
  "any_of": [
    {
      "finding": "svc_syndrome_present",
      "value": true
    },
    {
      "finding": "facial_upper_extremity_edema",
      "value": true
    },
    {
      "finding": "distended_neck_veins",
      "value": true
    }
  ],
  "type": "composite"
}

Notes

SVC syndrome occurs in ~5-10% of NSCLC at presentation. Per NCCN-NSCLC: emergency endovascular SVC stenting OR urgent palliative RT (30 Gy/10 fx) is first-line stabilization; chemoradiation begun in parallel for limited-stage; systemic therapy started thereafter for metastatic. Direction HOLD on definitive systemic therapy until SVC obstruction relieved (stent or RT). Priority 12. STUB — requires clinical co-lead signoff.

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