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MDS-HR patient transplanté admissible : âge < 70-75 (par pratique locale), HCT-CI ≤4, adéquat...

Vue déterministe de l'entité source de la LJAM. L'autorité clinique demeure avec les ID de la source cités et l'état d'approbation de l ́examinateur.

IDRF-MDS-TRANSPLANT-ELIGIBLE
TypeSignal d’alerte
Étatreviewed 2026-04-25 | pending_clinical_signoff
MaladiesDIS-MDS-HR
SourcesSRC-ESMO-MDS-2021 SRC-NCCN-AML-2025

Origine du drapeau rouge

DéfinitionMDS-HR patient transplant-eligible: age <70-75 (per local practice), HCT-CI ≤4, adequate organ function, donor available — initiate alloHCT donor search at HMA initiation, not at HMA failure
Direction cliniqueintensifier
Catégoriehigh-risk-biology
Algorithme de décalageALGO-MDS-HR-1L

Logique de déclenchement

{
  "any_of": [
    {
      "finding": "transplant_eligible",
      "value": true
    },
    {
      "all_of": [
        {
          "comparator": "<",
          "finding": "age_years",
          "threshold": 70
        },
        {
          "comparator": "<=",
          "finding": "hct_ci_score",
          "threshold": 4
        },
        {
          "finding": "ipss_r_category",
          "value": "high"
        }
      ]
    }
  ],
  "type": "composite"
}

Notes

AlloHCT is the only curative option for MDS-HR; survival benefit consistently demonstrated in IPSS-R high / very-high. Biological-age + comorbidity + donor + caregiver support determine eligibility, not chronological age alone (HCT-CI / Sorror score is the key tool). Triggers donor search initiation alongside HMA — do NOT wait for HMA failure as donor search takes 3-6 months. STUB — requires clinical co-lead signoff.

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