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MDS-HR patient transplant-eligible: age <70-75 (per local practice), HCT-CI ≤4, adequate...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

Red Flag Origin

Trigger Logic

{
  "any_of": [
    {
      "finding": "transplant_eligible",
      "value": true
    },
    {
      "all_of": [
        {
          "comparator": "<",
          "finding": "age_years",
          "threshold": 70
        },
        {
          "comparator": "<=",
          "finding": "hct_ci_score",
          "threshold": 4
        },
        {
          "finding": "ipss_r_category",
          "value": "high"
        }
      ]
    }
  ],
  "type": "composite"
}

Notes

AlloHCT is the only curative option for MDS-HR; survival benefit consistently demonstrated in IPSS-R high / very-high. Biological-age + comorbidity + donor + caregiver support determine eligibility, not chronological age alone (HCT-CI / Sorror score is the key tool). Triggers donor search initiation alongside HMA — do NOT wait for HMA failure as donor search takes 3-6 months. STUB — requires clinical co-lead signoff.

Used By

Algorithms

• ALGO-MDS-HR-1L - ALGO-MDS-HR-1L
• ALGO-MDS-HR-2L - ALGO-MDS-HR-2L

Indications

• IND-MDS-HR-1L-AZA - IND-MDS-HR-1L-AZA
• IND-MDS-HR-ALLOHCT - IND-MDS-HR-ALLOHCT