Doxazosin
Vue déterministe de l'entité source de la LJAM. L'autorité clinique demeure avec les ID de la source cités et l'état d'approbation de l ́examinateur.
| ID | DRUG-DOXAZOSIN |
|---|---|
| Type | Médicament |
| Alias | Cardurablocant alpha-1 sélectifДоксазозин |
| État | reviewed 2026-07-11 | pending_clinical_signoff |
| Maladies | DIS-PHEOCHROMOCYTOMA |
| Sources | SRC-ENDOCRINE-SOCIETY-PPGL-2014 SRC-NCCN-NET-2025 |
Faits sur les drogues
| Catégorie | Antagoniste sélectif et compétitif des récepteurs adrénergiques alpha-1 |
|---|---|
| Mécanisme | Selectively and reversibly blocks post-synaptic alpha-1 adrenergic receptors, reducing catecholamine-mediated peripheral vasoconstriction with less reflex tachycardia than non-selective irreversible agents (phenoxybenzamine) because alpha-2 presynaptic auto-inhibition of norepinephrine release is preserved. Used as an alternative preoperative alpha-blocker in pheochromocytoma / paraganglioma (PPGL) where mandatory preoperative alpha-blockade is required before surgery to prevent intraoperative hypertensive crisis (Endocrine Society 2014 PPGL guideline). |
| Dose typique | Starting dose typically 1-2 mg PO once daily, titrated upward every few days as tolerated toward blood-pressure normalization and symptom control ahead of PPGL surgery, per Endocrine Society 2014 PPGL guideline (SRC-ENDOCRINE-SOCIETY-PPGL-2014); usual ceiling in general antihypertensive use is 16 mg/day, though the dose actually required for adequate preoperative PPGL blockade is individualized by the treating team. Usual preoperative course runs roughly one to two weeks before surgery. Exact target BP/HR thresholds are NOT fixed numeric values in this stub -- see RF-PHEO-INADEQUATE-ALPHA-BLOCKADE for the hard sequencing gate this drug exists to satisfy. |
| Ukraine enregistrée | Vrai |
| NSZU remboursé | Faux |
| Ukraine vérifiée pour la dernière fois | 2026-07-11 |
Notes
Selective alpha-1 blockade gives less reflex tachycardia and easier general availability than phenoxybenzamine (DRUG-PHENOXYBENZAMINE), making doxazosin a commonly used practical alternative for mandatory preoperative PPGL alpha-blockade; choice between the two is per local practice/availability, not modelled as a KB-level preference. STUB pending clinical co-lead signoff (CHARTER §6.1, dev-mode-exempted).
Utilisé par
Médicament
DRUG-PHENOXYBENZAMINE- Phenoxybenzamine
Protocole thérapeutique
REG-ALPHA-BLOCKADE-PREOP-PHEO- blocus alpha-adrénergique préopératoire (phenoxybenzamine, avant le phéochromocytome/paragan...